Grafe Fruit Extract (Vitis vinifera) as an antioxidant
DOI:
https://doi.org/10.51601/ijhp.v2i1.12Keywords:
Vitis vinivera, antioksidan, DPPH, ABTS, LC-MS/MSAbstract
One plant that is believed to have anti-diabetic effects is grapes (Vitis vinifera), which contains polyphenol compounds. The antioxidant and anti-postprandial hyperglycemics of grape extract show potential in treating diabetes. This study is an experimental study that aims to explore grape extract extracts as antioxidants through testing (DPPH, ABTS, LC-MS/MS). Based on the test results, grape extract contains very high phytochemicals, including terpenoids and alkaloids, and antioxidant test results found DPPH with an average IC50 value of 21.49 g / mL and at the lowest concentration (6.25 g / mL). The GFE also showed the highest antioxidant activity against ABTS trapping with an average IC50 value of 74.07 g/mL and LC-MS/MS results obtained grape extract samples containing 0.00001% chlorogenic acid and querce-tin compounds of 0.00012%.
References
Setiati S. Radikal bebas, antioksidan, dan proses menua. Medika 2003; 6:366-9.
Shihabi A, Li WG, Miller Jr FG, Weintraub NL. Antioxidant therapy for atherosclerotic vascular disease: the
promise and the pitfalls. Am J Physiol Heart Circ Physiol [serial online]. 2002 [disitasi bulan Maret 2009]; 282
(3): 797-802.
Giacco F, Brownlee M. Oxidative Stress and Diabetic Complications. Circ Res [serial online]. 2010 [disitasi
tanggal 29 July 2013];107:1058-70.
Ramamurthy et al, 2013 Ramamurthy, C., Sampath, K. S., Arunkumar, P., Suresh Kumar, M., Sujatha, V.,
Premkumar, K., and Thirunavukkarasu, C. (2013). Green synthesis and characterization of selenium
nanoparticles and its augmented cytotoxicity with doxorubicin on cancer cells. Bioprocess and Biosystems
Engineering, 36(8), 1131-1139.
Vaya dan Aviram, 2001. Vaya, J, Aviram, M. 2001. Nutritional antioxidant : mechanism of action, analyses of
activities and medical applications, Curr. Med. ChemImm,Endoc. &Metab Agents
Papas, 1999; Halliwel dan Gutteridge, 1999. Papas, A.M. 1999. Antioxidant Status, Diet,
Sun, C., Liu, Y., Zhan, L., Rayat, G. R., Xiao, J., Jiang, H., Chen, K. Anti-diabetic effects of natural antioxidants
from fruits. Trends in Food Science & Technology. 2020
Gourineni, Vishnupriya & Shay, Neil & Chung, Soonkyu & Sandhu, Amandeep & Gu, Liwei. Muscadine Grape
(Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity- Associated Metabolic Complications in
C57BL/6J Mice. Journal of agricultural and food chemistry. 2012; 60. 7674-81. 10.1021
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Hartono, I Nyoman Ehrich Lister, Buter Samin

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.