Providing Of Mahkota Dewa Fruit Extract (Phaleria Macrocarpa) To Reduce Malondialdehyde Levels In The Blood Of White Rats (Rattus Norvegicus) Triggered By Excessive Physical Activity
DOI:
https://doi.org/10.51601/ijhp.v3i4.305Keywords:
Phaleria macrocarpa, Malondialdehyde, Oxidative stress and Lipid peroxidation.Abstract
Anti-inflammatory, antioxidant, and apoptosis-modulating potential are just a few biological
activities that have garnered much interest in natural food-derived components during the
past two decades. Mahkota Dewa fruit (Phaleria macrocarpa) has several beneficial
pharmacological activities. This study investigated whether Mahkota Dewa fruit extract
(Phaleria macrocarpa) reduced malondialdehyde levels in blood samples of white rats
(Rattus norvegicus) generated by excessive physical activity. The samples for this study were
white rats (Rattus norvegicus) weighing 160-200 gr and 2-3 months old. The independent
variable was the Mahkota Dewa fruit extract (Phaleria macrocarpa). The dependent variable
was excessive physical activity-induced malondialdehyde levels in white rats (Rattus
norvegicus). The average Malondialdehyde (MDA) levels show that the group given 5 ml of
the Mahkota Dewa fruit extract (Phaleria macrocarpa) had tremendous success in lowering
MDA levels compared to the other groups. The results of the observations and data analysis
show that administration of the extract can reduce MDA levels significantly in male Wistar
rats (Rattus norvegicus) because of too much exercise.
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