Effectiveness of Applying Anti-Aging Cream with Lemon Peel Extract (Citrus Limon) in Inhibiting the Skin Aging Process of Wistar Rats (Rattus Norvegicus) Exposed to Ultra Violet-B Rays
DOI:
https://doi.org/10.51601/ijhp.v3i4.308Keywords:
UV Radiation, Citrus Limon Extract and Anti-Aging.Abstract
Aging is a gradual physiological change in an organism that results in senescence or a reduction in biological function and the ability of the organism to respond to metabolic stress. Aging occurs in cells, organs, or the entire organism over time; the study of the aging process seeks to understand and regulate all elements that contribute to an individual's life constraints. The predominant acute consequence of UV radiation on normal human skin is sunburn-induced inflammation (erythema). The overall goal of this study is to examine and test the efficacy of applying an anti-aging cream containing lemon peel extract (Citrus limon) in preventing the aging process of mouse skin. Wistar strain (Rattus norvegicus) exposed to ultraviolet-B light. The specific goal of this study is to investigate the efficacy of applying lemon peel extract (Citrus limon) cream at 5%, 10%, and 15% concentrations in preventing the aging process of rat skin exposed to UV-B radiation.
References
Z. D. Draelos and A. Shamban, “A pilot study evaluating the anti-aging benefits of a CO2-emitting facial mask,” J. Cosmet. Dermatol., vol. 22, no. 8, pp. 2198–2204, 2023, doi: 10.1111/jocd.15860.
V. Rizzi, J. Gubitosa, P. Fini, and P. Cosma, “Neurocosmetics in skincare-the fascinating world of skin-brain connection: A review to explore ingredients, commercial products for skin aging, and cosmetic regulation,” Cosmetics, vol. 8, no. 3, 2021, doi: 10.3390/cosmetics8030066.
I. Popescu, J. Deelen, M. Illario, and J. Adams, “Challenges in anti-aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan,” J. Cell. Mol. Med., vol. 27, no. 18, pp. 2643–2650, 2023, doi: 10.1111/jcmm.17912.
C. Bigonnesse and H. Chaudhury, “The Landscape of ‘Aging in Place’ in Gerontology Literature: Emergence, Theoretical Perspectives, and Influencing Factors,” J. Hous. Elderly, vol. 34, no. 3, pp. 233–251, 2019, doi: 10.1080/02763893.2019.1638875.
L. Simon, C. Picard, L. S. Calixto, V. Lapinte, J. M. Devoisselle, and S. Bégu, “Study of the physicochemical interactions of nanoformulations based on poly oxazolines with a skin surface model,” Colloids Surfaces A Physicochem. Eng. Asp., vol. 626, pp. 1–13, 2021, doi: 10.1016/j.colsurfa.2021.127027.
T. M. Ansary, M. R. Hossain, K. Kamiya, M. Komine, and M. Ohtsuki, “Inflammatory molecules associated with ultraviolet radiation‐mediated skin aging,” Int. J. Mol. Sci., vol. 22, no. 8, 2021, doi: 10.3390/ijms22083974.
B. Woodby, K. Penta, A. Pecorelli, M. A. Lila, and G. Valacchi, “Skin Health from the Inside out,” Annu. Rev. Food Sci. Technol., vol. 11, no. March, pp. 235–254, 2020, doi: 10.1146/annurev-food-032519-051722.
V. W. Fam, P. Charoenwoodhipong, R. K. Sivamani, R. R. Holt, C. L. Keen, and R. M. Hackman, “Plant-Based Foods for Skin Health: A Narrative Review,” J. Acad. Nutr. Diet., vol. 122, no. 3, pp. 614–629, 2022, doi: 10.1016/j.jand.2021.10.024.
A. Aslam, A. Bahadar, R. Liaquat, M. Saleem, A. Waqas, and M. Zwawi, “Science of the Total Environment Algae as an attractive source for cosmetics to counter environmental stress,” Sci. Total Environ., vol. 772, p. 144905, 2021, doi: 10.1016/j.scitotenv.2020.144905.
M. A. Nilforoushzadeh et al., “Skin care and rejuvenation by cosmeceutical facial mask,” J. Cosmet. Dermatol., vol. 17, no. 5, pp. 693–702, 2018, doi: 10.1111/jocd.12730.
C. Messaraa et al., “Clinical evidences of benefits from an advanced skin care routine in comparison with a simple routine,” J. Cosmet. Dermatol., vol. 19, no. 8, pp. 1993–1999, 2020, doi: 10.1111/jocd.13252.
Y. Matsumura and H. N. Ananthaswamy, “Toxic effects of ultraviolet radiation on the skin,” Toxicol. Appl. Pharmacol., vol. 195, no. 3, pp. 298–308, 2004, doi: 10.1016/j.taap.2003.08.019.
K. J. Gromkowska-Kępka, A. Puścion-Jakubik, R. Markiewicz-Żukowska, and K. Socha, “The impact of ultraviolet radiation on skin photoaging — review of in vitro studies,” J. Cosmet. Dermatol., vol. 20, no. 11, pp. 3427–3431, 2021, doi: 10.1111/jocd.14033.
C. S. Enwemeka, T. L. Baker, and V. V. Bumah, “The role of UV and blue light in photo-eradication of microorganisms: Photo-Eradication of Microorganisms,” J. Photochem. Photobiol., vol. 8, p. 100064, 2021, doi: 10.1016/j.jpap.2021.100064.
C. Winarti, Innawati, and Hemani, “Physical Characteristics and UV Protection (In Vitro) of Gambier Leaf Extract Lotion,” IOP Conf. Ser. Earth Environ. Sci., vol. 1024, no. 1, 2022, doi: 10.1088/1755-1315/1024/1/012061.
A. M. Anshori, A. A. G. P. Wiraguna, and W. Pangkahila, “Pemberian oral ekstrak kulit buah lemon (Citrus limon) menghambat peningkatan ekspresi MMP-1 (matrix metaloproteinase-1) dan penurunan jumlah kolagen pada tikus putih galur wistar jantan (Rattus norvegicus) yang dipajan sinar UV-B,” J. e-Biomedik, vol. 5, no. 1, pp. 3–7, 2017, doi: 10.35790/ebm.5.1.2017.15036.
S. Notoatmodjo, Metodologi Penelitian Kesehatan, 3rd ed. Jakarta: Rineka Cipta, 2018.
B. Suwarno and A. Nugroho, Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi & Artikel Publikasi), 1st ed. Bogor: Halaman Moeka Publishing, 2023.
L. V. Kendall et al., “Replacement, Refinement, and Reduction in Animal Studies With Biohazardous Agents,” ILAR J., vol. 59, no. 2, pp. 177–194, 2018, doi: 10.1093/ilar/ily021.
I. Ghozali, Aplikasi Analisis Multivariate dengan Program IBM SPSS 25. Semarang, 2018.
T. L. Fernandez, D. R. Van Lonkhuyzen, R. A. Dawson, M. G. Kimlin, and Z. Upton, “Characterization of a human skin equivalent model to study the effects of ultraviolet B radiation on keratinocytes,” Tissue Eng. - Part C Methods, vol. 20, no. 7, pp. 588–598, 2014, doi: 10.1089/ten.tec.2013.0293.
M. H. A. M. AL-kahfaji, “Human Skin Infection A Review Study,” Biomed. Chem. Sci., vol. 1, no. 4, pp. 254–258, 2022, doi: 10.48112/bcs.v1i4.259.
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