Effectiveness of Dermapen Action Using Green Belt Leaf Extract Cream (Piper betle L) On Hair Growth on The Skin Surface of Female Wistar Strain Rats (Rattus Norvegicus)

Authors

  • Novy Hardianti Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan, Indonesia
  • Henny Henny Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan, Indonesia
  • Taufik Delfian Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan, Indonesia

DOI:

https://doi.org/10.51601/ijhp.v3i4.311

Abstract

Hair loss is a very prevalent hair issue. Hair loss is typical for all humans, but if it becomes severe, it can lead to baldness. Hair goes through a unique cycle of development and loss for each strand, and one herbal plant that has the activity of fertilizing hair growth and overcoming the problem of hair loss is green betel leaf (Piper betle L). The purpose of this study was to determine the efficacy of a derma pen utilizing green betel leaf extract cream (Piper betle L) on hair development on the skin surface of female Wistar rats (Rattus norvegicus). Betel leaves have been shown to help with issues such as hair loss. Using betel leaves regularly aids in It promotes hair growth, conditions hair, and makes it thick and long. Betel leaves can also assist with itching, dandruff, and broken ends. The polyphenol and flavonoid content in betel leaves is an antioxidant and anti-inflammatory, protecting hair from damage caused by inflammatory skin illnesses and free radicals that cause hair loss on the head.

References

Syilfiana Anwar and Fitrianti Darusman, “Hair Tonic dengan Kandungan Senyawa yang Memiliki Aktivitas

Penumbuh Rambut dari Berbagai Bahan Herbal,” Bandung Conf. Ser. Pharm., vol. 2, no. 2, pp. 1–8, 2022, doi:

29313/bcsp.v2i2.4366.

H. Morinaga et al., “Obesity Accelerates Hair Thinning By Stem Cell-centric Converging Mechanism,” Nature,

vol. 595, no. 7866, pp. 266–271, 2021, doi: 10.1038/s41586-021-03624-x.Obesity.

M. J. Bertoli, R. Sadoughifar, R. A. Schwartz, T. M. Lotti, and C. K. Janniger, “Female Pattern Hair Loss: A

Comprehensive Review,” Dermatol. Ther., vol. 33, no. 6, pp. 1–5, 2020, doi: 10.1111/dth.14055.

L. Dhami, “Psychology of Hair Loss Patients and Importance of Counseling,” Indian J. Plast. Surg., vol. 54, no.

, pp. 411–415, 2021, doi: 10.1055/s-0041-1741037.

S. Vañó-Galván et al., “Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients,” J.

Am. Acad. Dermatol., vol. 84, no. 6, pp. 1644–1651, 2021, doi: 10.1016/j.jaad.2021.02.054.

M. Randolph and A. Tosti, “Oral minoxidil treatment for hair loss: A review of efficacy and safety,” J. Am.

Acad. Dermatol., vol. 84, no. 3, pp. 737–746, 2021, doi: 10.1016/j.jaad.2020.06.1009.

M. Madhumita, P. Guha, and A. Nag, “Bio-actives of betel leaf (Piper betle L.): A comprehensive review on

extraction, isolation, characterization, and biological activity,” Phyther. Res., vol. 34, no. 10, pp. 2609–2627,

, doi: 10.1002/ptr.6715.

P. V. Devidas and D. L. D. Hingne, “Formulation and Evaluation of Herbal Shampoo from Piper Betel and

Psidium Guajava Leaves,” Int. J. Res. Appl. Sci. Eng. Technol., vol. 10, no. 6, pp. 3792–3800, 2022, doi:

22214/ijraset.2022.44985.

J. Yoonus, R. Resmi, and B. Beena, “Greener nanoscience: Piper betel leaf extract mediated synthesis of CaO

nanoparticles and evaluation of its antibacterial and anticancer activity,” Mater. Today Proc., vol. 41, no. xxxx,

pp. 535–540, 2020, doi: 10.1016/j.matpr.2020.05.246.

K. N. Ozcan, S. Sener, N. Altunisik, and D. Turkmen, “Platelet rich plasma application by dermapen

microneedling and intradermal point‐by‐point injection methods, and their comparison with clinical findings and

trichoscan in patients with androgenetic alopecia,” Dermatol. Ther., vol. 35, no. 1, p. e15182, 2022.

B. S. Atiyeh, O. Abou Ghanem, and F. Chahine, “Microneedling: Percutaneous Collagen Induction (PCI)

Therapy for Management of Scars and Photoaged Skin—Scientific Evidence and Review of the Literature,”

Aesthetic Plast. Surg., vol. 45, no. 1, pp. 296–308, 2021, doi: 10.1007/s00266-020-01927-4.

M. M. Omar, Z. M. Obaid, and O. M. E. Sayedahmed, “Comparative study between topical application of

triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the treatment of resistant

alopecia areata,” Dermatol. Ther., vol. 35, no. 12, p. e15913, 2022.

S. Notoatmodjo, Metodologi Penelitian Kesehatan, 3rd ed. Jakarta: Rineka Cipta, 2018.

B. Suwarno and A. Nugroho, Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi &

Artikel Publikasi), 1st ed. Bogor: Halaman Moeka Publishing, 2023.

C. Li, Y. Li, X. Gao, and H. Lv, “Rutaecarpine dissolved in binary aqueous solutions of methanol, ethanol,

isopropanol and acetone: Solubility determination, solute-solvent and solvent-solvent interactions and

preferential solvation study,” J. Chem. Thermodyn., vol. 151, p. 106253, 2020, doi: 10.1016/j.jct.2020.106253.

P. A. Anwar, A. N. Nasution, S. W. Nasution, S. L. R. Nasution, H. M. Kurniawan, and E. Girsang, “Uji

Efektivitas Ekstrak Daun Sirih Hijau ( Piper betle L) Terhadap Pertumbuhan Jamur Pityrosporum ovale pada

Ketombe,” J. Farm., vol. 1, no. 1, pp. 32–37, 2019.

Downloads

Published

2024-08-28

How to Cite

Hardianti, N. ., Henny, H., & Delfian, T. . (2024). Effectiveness of Dermapen Action Using Green Belt Leaf Extract Cream (Piper betle L) On Hair Growth on The Skin Surface of Female Wistar Strain Rats (Rattus Norvegicus). International Journal of Health and Pharmaceutical (IJHP), 4(3), 541–546. https://doi.org/10.51601/ijhp.v3i4.311

Issue

Section

Articles