Literature Review: Factors Affecting Tuberculosis Recurrence in Indonesia
DOI:
https://doi.org/10.51601/ijhp.v5i3.422Abstract
Tuberculosis (TB) remains a significant public health challenge in Indonesia, with relapse contributing substantially to the ongoing disease burden. This systematic literature review aims to identify and synthesize factors affecting TB recurrence in Indonesia, providing insights for targeted interventions. The study employed a comprehensive search across Google Scholar, PubMed, and ScienceDirect using keywords in both English and Bahasa Indonesia, focusing on articles published between 2015 and 2025. A total of 10 primary research articles meeting the inclusion criteria were analyzed, encompassing retrospective, cohort, and cross-sectional designs. Data were extracted on variables such as behavioral, socioeconomic, healthcare, biological, and environmental factors, then synthesized to determine their association with TB relapse. Findings consistently highlight smoking habits, medication non-adherence, low education, inadequate housing ventilation, comorbidities like diabetes, and household contact with TB patients as significant risk factors. Despite heterogeneity in study methodologies, these results underscore the multifaceted nature of TB relapse determinants. The review concludes that integrated strategies addressing behavioral, socioeconomic, and environmental factors are crucial for TB control efforts in Indonesia. Future research should focus on longitudinal and multicenter studies to establish causality and evaluate intervention efficacy. These insights are vital to inform policies aimed at reducing TB recurrence and achieving Indonesia’s goal of TB elimination by 2030.
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References
World Health Organization, Tuberculosis. Geneva: WHO, 2025. [Online]. Available: https://www.who.int/health-topics/tuberculosis#tab=tab_1
K. Lönnroth, E. Jaramillo, and C. Dye, "The global burden of tuberculosis: Lessons from a century of progress and challenges," Infectious Disease Clinics of North America, vol. 37, no. 1, pp. 1-18, Jan. 2023.
World Health Organization, Global tuberculosis report 2024. Geneva: WHO, 2024. [Online]. Available: https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2024
R. A. Dlodlo, B. B. Bwalya, and P. Musonda, "Trends and projections of tuberculosis incidence in sub-Saharan Africa: A systematic review and meta-analysis," Journal of Public Health in Africa, vol. 15, no. 1, pp. 1-10, Jan. 2024.
C. T. Mithunage and D. W. Denning, "Timing of recurrence after treatment of pulmonary TB," IJTLD open, vol. 1, no. 10, pp. 456–465, May 2024.
J. L. Chan, K. G. Sun, and A. L. Miller, "Smoking and tuberculosis: A systematic review and meta-analysis of the immunological impact," Lung, vol. 203, no. 2, pp. 125-134, Mar. 2025.
World Bank, Tuberculosis in Indonesia: Epidemic projections and opportunities to accelerate control. Washington, DC: World Bank Group, 2020.
S. Khan and A. D. Ali, "Diabetes mellitus and tuberculosis: A review of the bidirectional relationship," Journal of Infectious Diseases and Epidemiology, vol. 8, no. 1, pp. 1023-1030, Feb. 2024.
L. M. Garcia, R. B. Perez, and C. D. Sanchez, "Impact of nutritional status on tuberculosis recurrence: A systematic review," Journal of Global Health Perspectives, vol. 1, no. 2, pp. 55-68, Jul. 2023.
D. K. Sharma and S. P. Singh, "Ageing and susceptibility to tuberculosis: Immunological considerations," Frontiers in Immunology, vol. 15, pp. 1-12, Apr. 2024.
Purnawan, H. Sukandar, and S. Susilawati, "Factors affecting tuberculosis relapse among adult patients in Indonesia: A systematic review," International Journal of Public Health Science (IJPHS), vol. 11, no. 2, pp. 522-530, Apr. 2022.
M. A. Fitri, S. Lestari, and B. Pradana, "Effectiveness of Directly Observed Treatment Short-course (DOTS) strategy on tuberculosis treatment outcomes in Indonesia: A systematic review," Indonesian Journal of Public Health, vol. 20, no. 1, pp. 45-56, Jan. 2025.
T. W. Susanto and R. Hidayati, "The role of health workers and family support in improving medication adherence among TB patients: A qualitative study," Journal of Community Health Research, vol. 9, no. 3, pp. 210-220, Sep. 2024.
World Health Organization, Tuberculosis: Multidrug-resistant (MDR-TB) or rifampicin-resistant TB (RR-TB). Geneva: WHO, 2024.
N. M. Lwin, M. T. Aung, N. N. Aung, K. Hlaing, S. Thein, and S. H. Oo, "Risk factors for multidrug-resistant tuberculosis in Myanmar: A systematic review and meta-analysis," Journal of Infection and Public Health, vol. 14, no. 1, pp. 13-20, Jan. 2021.
T. Xi et al., "Risk factors for multidrug-resistant tuberculosis: A meta-analysis," Frontiers in Public Health, vol. 9, p. 763943, Nov. 2021.
R. Gai, S. Tan, R. Tang, W. Wang, S. Wang, H. Wang, and R. Chen, "Post-tuberculosis lung disease: A narrative review," Journal of Thoracic Disease, vol. 14, no. 12, pp. 4811-4821, Dec. 2022.
N. Gupte, A. Kruk, F. S. Sarfo, and A. Gupta, "The global burden of post-tuberculosis lung disease and its management: A systematic review," Lancet Global Health, vol. 10, no. 12, pp. e1744-e1755, Dec. 2022.
T. A. Jhaveri et al., "Clinical outcomes of individuals with COVID-19 and tuberculosis during the pre-vaccination period of the pandemic: A systematic review," J Clin Med, vol. 11, no. 19, p. 5656, Sep. 2022.
Kementerian Kesehatan Indonesia, Strategi Nasional Penanggulangan Tuberkulosis Tahun 2020-2024. Jakarta: Kementerian Kesehatan Republik Indonesia, 2021.
C. M. Page et al., "The PRISMA 2020 statement: An updated guideline for reporting systematic reviews," BMJ, vol. 372, p. n71, Mar. 2021.
Sugiyono, Metode Penelitian Kuantitatif, Kualitatif, dan R&D. Bandung: Alfabeta, 2022.
S. M. Sudaryono and N. S. H. Siregar, "Literature review: Peran literatur review dalam pengembangan penelitian ilmiah," Jurnal Penelitian dan Pengembangan Ilmu Pendidikan, vol. 6, no. 1, pp. 10-18, Jan. 2022.
D. Moher, A. Liberati, J. Tetzlaff, and D. G. Altman, "Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement," PLoS medicine, vol. 6, no. 7, p. e1000097, Jul. 2009.
M. J. Page et al., "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews," BMJ, vol. 372, p. n71, Mar. 2021.
B. P. Sukmaningtyas, L. Widagdo, and P. Ginandjar, "Faktor-faktor yang berhubungan dengan kekambuhan tuberkulosis paru," Jurnal Kesehatan Masyarakat, vol. 4, no. 2, pp. 22-31, 2016.
L. Ratnawati and S. Arifin, "Hubungan karakteristik pasien dengan kejadian kekambuhan pada pasien tuberkulosis paru di RSI PKU Muhammadiyah Pekajangan Pekalongan," Jurnal Ilmiah Kesehatan, vol. 14, no. 2, pp. 241-248, 2022.
K. Jaya and Y. Mediarti, "Faktor-faktor risiko yang berhubungan dengan kejadian tuberkulosis paru relaps di Rumah Sakit Khusus Paru Provinsi Sumatera Selatan tahun 2016," Jurnal Ilmu Kesehatan Masyarakat, vol. 8, no. 1, pp. 1-6, 2017.
J. N. Tumiwa, S. H. Rampengan, and D. H. Wowiling, "Faktor-faktor determinan yang berhubungan dengan kejadian ulang (relaps) pada penderita tuberkulosis paru di RSUD Amurang," Jurnal Kedokteran Komunitas dan Epidemiologi, vol. 2, no. 1, pp. 1-8, 2023.
R. Ulfa, S. Susilawati, and D. F. Sari, "Gambaran faktor-faktor risiko yang berkontribusi terhadap kejadian TB paru kambuh di Puskesmas Kota Jambi tahun 2020–2022," Jurnal Kesehatan Masyarakat, vol. 7, no. 1, pp. 121-128, 2023.
Kusumajaya, "Faktor-faktor yang berhubungan dengan kekambuhan pada pasien tuberkulosis paru," Jurnal Ilmiah Kesehatan, vol. 16, no. 1, pp. 45-52, 2024.
E. Nurwanti and M. Wahyono, "Faktor penjamu (host) dan faktor lingkungan (environment) yang berhubungan dengan kejadian TB paru relaps di puskesmas se-Kota Semarang," Jurnal Kesehatan Masyarakat, vol. 5, no. 1, pp. 1-9, 2016.
S. Yunita, R. Ningsih, and R. Puspita, "Hubungan kepatuhan dalam minum obat serta motivasi keluarga dengan kekambuhan penyakit TB paru," Jurnal Kesehatan Komunitas, vol. 7, no. 2, pp. 79-84, 2020.
E. Siburian, H. Nainggolan, and D. Sihombing, "Faktor-faktor yang menjadi penyebab kekambuhan kasus Tuberkulosis paru secara umum," Jurnal Kedokteran dan Kesehatan, vol. 15, no. 2, pp. 114-121, 2019.
N. L. Karminiasih, P. Astuti, and K. Suryana, "Faktor-faktor risiko yang berhubungan dengan kekambuhan penderita TB paru di Kota Denpasar," Jurnal Kesehatan Lingkungan, vol. 6, no. 1, pp. 1-8, 2016.
Emzir, Metodologi Penelitian Kualitatif Analisis Data. Jakarta: Rajawali Pers, 2023.
D. Putra, S. K. Lestari, and B. W. Pramono, "Health literacy and adherence to tuberculosis treatment: A systematic review," Journal of Public Health Research and Development, vol. 12, no. 2, pp. 88-99, Apr. 2024.
R. Utami, D. P. Sari, and E. N. Putri, "The role of family support in improving adherence to medication among chronic disease patients: A literature review," International Journal of Nursing Science and Practice, vol. 5, no. 1, pp. 1-10, Jan. 2025.
Y. B. Permana, N. Anggraini, and H. Setiawan, "Impact of social support on treatment outcomes for tuberculosis patients in Indonesia," Journal of Health Promotion and Behavior, vol. 10, no. 3, pp. 123-135, Sep. 2024.
C. K. Lee, J. Y. Kim, and S. H. Park, "Family-centered care in tuberculosis management: A systematic review of intervention effectiveness," Journal of Global Health Perspectives, vol. 1, no. 1, pp. 20-35, Mar. 2023.
World Health Organization, WHO guidelines on tuberculosis infection prevention and control. Geneva: WHO, 2024. [Online]. Available: https://www.who.int/publications/i/item/9789240097725
World Health Organization, The End TB Strategy. Geneva: WHO, 2023. [Online]. Available: https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/the-end-tb-strategy
D. S. Riwu, M. P. Simbolon, and A. H. R. Tobing, "Housing conditions and tuberculosis transmission: A systematic review and meta-analysis," Environmental Health and Preventive Medicine, vol. 29, no. 1, pp. 1-15, Jan. 2024.
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