Comparison of the Effectiveness of Antihypertensive Drugs Captopril 25 mg and Amlodipine 5 mg in Lowering Blood Pressure in Hypertensive Patients
DOI:
https://doi.org/10.51601/ijhp.v5i4.455Abstract
Hypertension is a major global health problem with increasing prevalence and significant risks of complications. This study aims to compare the effectiveness of Captopril 25 mg and Amlodipine 5 mg in lowering blood pressure among hypertensive patients. An analytical observational study with a cross-sectional design was conducted at Waruroyom Community Health Center, involving 70 patients divided equally into two groups. Data were collected using structured questionnaires, medication adherence sheets, and calibrated digital blood pressure monitors. Univariate and bivariate analyses were performed, including paired T-tests and Mann-Whitney tests. The results showed that both Captopril and Amlodipine effectively reduced systolic and diastolic blood pressure. However, Amlodipine 5 mg demonstrated a significantly greater reduction in diastolic blood pressure compared to Captopril 25 mg, while both drugs had similar effects on systolic blood pressure. The conclusion is that Amlodipine may be preferred for patients requiring greater diastolic blood pressure control, although both drugs are effective for systolic reduction.
Downloads
References
Bulan, M. I., Annisaa, E., & Dini, I. R. E. (2022). Cost effectiveness analysis of captopril and amlodipine in hypertensive patients with diabetes mellitus at Magelang Regency Health Center. Diponegoro Medical Journal, 11(5), 237–241. https://doi.org/10.14710/dmj.v11i5.237-241
Cresswell, J. W., & Creswell, J. D. (2022). Research design: Qualitative, quantitative, and mixed methods approaches (5th ed.). SAGE Publications.
Emzir. (2021). Metodologi penelitian pendidikan: Kuantitatif dan kualitatif. Rajawali Pers.
Farida, Y., & Tsalatsatun, K. F. (2021). Adverse drug reactions study of antihypertensive drugs in primary care settings. Jurnal Manajemen dan Pelayanan Farmasi, 10(4), 241–248. https://doi.org/10.25184/jmpf.v10i4.241
Katzung, B. G. (2018). Basic & clinical pharmacology (14th ed.). McGraw-Hill Education.
Kemenkes. (2021). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07 Tahun 2021 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Hipertensi Dewasa. Kementerian Kesehatan Republik Indonesia.
Kemenkes. (2023). Survei Kesehatan Indonesia (SKI) dalam angka. Kementerian Kesehatan Republik Indonesia.
Khairiyah, U., Akib Yuswar, M., & Umilia Purwanti, N. (2023). Pola penggunaan obat antihipertensi pada pasien hipertensi di instalasi rawat jalan rumah sakit. Jurnal Syifa Science and Clinical Research, 4(3), 609–617. https://doi.org/10.31604/jsscr.v4i3.609-617
Muhadi. (2016). JNC 8: Evidence-based guideline penanganan pasien hipertensi dewasa. Cermin Dunia Kedokteran, 43(1), 54–59.
Mansoor, K., Khan, H. W., Khattak, M. I., Imran, M., Tahir, H. B., & Zia, Q. (2022). Comparison between the efficacy of amlodipine with captopril in the management of uncontrolled blood pressure in the emergency department. Pakistan Armed Forces Medical Journal, 72(6), 2074–2077. https://doi.org/10.51253/pafmj.v72i6.2074
Mpila, D. A., & Lolo, W. A. (2022). Hubungan rasionalitas penggunaan obat antihipertensi terhadap outcome klinis pasien hipertensi di Klinik Imanuel Manado. Pharmacon, 11(1), 1350–1358. https://doi.org/10.35799/pha.11.2022.1350-1358
Nuryanti, E., Wardhana, M. F., & Damayanti, E. (2024). Perbandingan efektivitas obat antihipertensi golongan ARB versus CCB terhadap penurunan tekanan darah pada pasien hipertensi. Medical Profession Journal Lampung, 14(4), 712–718. https://doi.org/10.24198/mpj.v14i4.712
Pratama, F., Feladita, N., & Primadiamanti, A. (2023). Evaluasi penggunaan obat antihipertensi pada pasien hipertensi rawat jalan di Puskesmas Rawajitu. Jurnal Farmasi Malahayati, 6(1), 76–89. https://doi.org/10.33024/jfm.v6i1.76
Profil Kesehatan Provinsi Jawa Barat. (2023). Profil Kesehatan Provinsi Jawa Barat Tahun 2023. Dinas Kesehatan Provinsi Jawa Barat.
Rahayuni, M. D., Sifai, I. A., & Pramitasari, R. (2024). Faktor yang berhubungan dengan tekanan darah pada masyarakat pekerja di wilayah Desa Penadaran Kecamatan Gubug Kabupaten Grobogan. Jurnal Occupational Health Hygiene and Safety, 2(1), 222–236. https://doi.org/10.31227/osf.io/22236
Sudaryono. (2023). Metodologi penelitian kuantitatif dan kualitatif untuk kesehatan. Bumi Medika.
Sugiyono. (2022). Metode penelitian kuantitatif, kualitatif, dan R&D (2nd ed.). Alfabeta.
World Health Organization. (2021). Guideline for the pharmacological treatment of hypertension in adults. https://doi.org/10.1016/S0140-6736(21)00259-9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Ichlasul Amal, Sri Marfuati, Rini Istisakinah
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
