Comparisonal Of Treatment Length And Laboratory Examination Comorbid And Non-Combid Disease On Covid 19 Patients At Hospital Royal Prima
DOI:
https://doi.org/10.51601/ijhp.v2i2.48Abstract
Covid-19 is an infectious disease caused by a new type of coronavirus with symptoms of acute respiratory distress such as fever, cough, and shortness of breath. The type of research is comparative research with secondary data collection of as many as 280 comorbid patients and 280 non-comorbid patients in the month of august 2021 – January 2022. Data were analyzed univariately, bivariate with test Mann Withney. The results of this study are: Based on the mean length of stay for comorbid patients was 12.22 higher than that of non-comorbid patients, which was 5.28. The results of the laboratory examination of leukocytes in comorbid patients were higher at 13.17 than in non-comorbid patients, namely 10.07. In contrast, platelets were smaller, namely 268.87 than non-comorbid patients, namely 278.91. Neutrophils in comorbid patients were 76.28 higher than non-comorbid patients, namely 61.13. The lymphocyte of comorbid patients was 13.28 smaller than that of non-comorbid patients, which was 25.93. The D-dimer of comorbid patients was not too much different, namely 1259.85 than that of non-comorbid patients, namely 557.16. The conclusion in this study is that there is a significant difference between length of stay and laboratory tests (leukocytes, platelets, neutrophils, lymphocytes, D-dimer) for comorbid and non-comorbid diseases in Covid-19 patients at Royal Prima Hospital Medan.
References
Arentz Matt, Eric Yim, Lindy Klaff, Sharukh Lokhandwala, MScFrancis X. Riedo, Maria Chong, ML (2015). Environmental Contamination and Viral Shedding in MERS Patients during MERS-CoV Outbreak in South Korea. Clinical Infectious Diseases, 62(6), 755–760. https://doi.org/10.1093/cid/civ1020
Burhan et al. (2020). COVID-19 MANAGEMENT GUIDELINES (1st ed.). PDPI, PERKI, PAPDI, PERDATIN, IDAI.
Cascella, M., Rajnik, M., Cuomo, A., Dulebohn, SC, & Di Napoli, R. (2020). Features, Evaluation and Treatment of Coronavirus (COVID-19). StatPearls. http://www.ncbi.nlm.nih.gov/pubmed/32150360
De Wit, E., Van Doremalen, N., Falzarano, D., & Munster, VJ (2016). SARS and MERS: Recent insights into emerging coronaviruses. Nature Reviews Microbiology, 14(8), 523–534. https://doi.org/10.1038/nrmicro.2016.81
Di Gennaro, F., Pizzol, D., Marotta, C., Antunes, M., Racalbuto, V., Veronese, N., & Smith, L. (2020). Coronavirus diseases (COVID-19) current status and future perspectives: A narrative review. International Journal of Environmental Research and Public Health, 17(8). https://doi.org/10.3390/ijerph17082690
Docherty, AB, Harrison, EM, Green, CA, Hardwick, H., Pius, R., Norman, L., Holden, KA, Read, JM, Dondelinger, F., Carson, G., Merson, L., Lee, J., Plotkin, D., Sigfrid, L., Halpin, S., Jackson, C., Gamble, C., Horby, PW, Nguyen-Van-Tam, JS, … Semple, MG (2020). Features of 16,749 hospitalized UK patients with COVID-19 using the ISARIC WHO Clinical Characterization Protocol. MedRxiv. https://doi.org/10.1101/2020.04.23.20076042
Fan, BE, Chong, VCL, Chan, SSW, Lim, GH, Lim, KGE, Tan, GB, Mucheli, SS, Kuperan, P., & Ong, KH (2020). Hematologic parameters in patients with COVID-19 infection. American Journal of Hematology, 95(6), E131–E134. https://doi.org/10.1002/ajh.25774
Fan, YY, Huang, ZT, Li, L., Wu, MH, Yu, T., Koup, RA, Bailer, RT, & Wu, CY (2009). Characterization of SARS-CoV-specific memory T cells from recovered individuals 4 years after infection. Archives of Virology, 154(7), 1093–1099. https://doi.org/10.1007/s00705-009-0409-6
Gao, Y., Li, T., Han, M., Li, X., Wu, D., Xu, Y., Zhu, Y., Liu, Y., Wang, X., & Wang, L. (2020). Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. Journal of Medical Virology, 92(7), 791–796. https://doi.org/10.1002/jmv.25770
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Liu, L., Shan, H., Lei, C., Hui, DSC, Du , B., Li, L., Zeng, G., Yuen, K.-Y., Chen, R., Tang, C., Wang, T., Chen, P., Xiang, J., … Zhong, N. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, 382(18), 1708–1720. https://doi.org/10.1056/nejmoa2002032
Guo, L., Ren, L., Yang, S., Xiao, M., Chang, D., Yang, F., Dela Cruz, CS, Wang, Y., Wu, C., Xiao, Y., Zhang, L., Han, L., Dang, S., Xu, Y., Yang, QW, Xu, SY, Zhu, HD, Xu, YC, Jin, Q., … Wang, J. (2020). Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clinical Infectious Diseases, 71(15), 778–785. https://doi.org/10.1093/cid/ciaa310
Han H, Luo Q, Mo F, Long L, ZW (2020). SARS-CoV-2 RNA more readily detected in induced sputum than in throat swabs of convalescent COVID-19 patients. The Lancet, 20(January), 655–656.
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
Hui, DS, I Azhar, E., Madani, TA, Ntoumi, F., Kock, R., Dar, O., Ippolito, G., Mchugh, TD, Memish, ZA, Drosten, C., Zumla, A ., & Petersen, E. (2020). The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China. International Journal of Infectious Diseases, 91, 264–266. https://doi.org/10.1016/j.ijid.2020.01.009
Isbaniah, et al. (2020). Guidelines for Preparedness for Coronavirus Disease (COVID-19). Director General of Disease Prevention and Control.
Jakovljević, M., & Ostojić, L. (2013). Comorbidity and multimorbidity in medicine today: challenges and opportunities for bringing separated branches of medicine closer to each other. In Psychiatria Danubina: Vol. 25 Suppl 1 (pp. 18–28).
Kam, KQ, Yung, CF, Cui, L., Pin Lin, RT, Mak, TM, Maiwald, M., Li, J., Chong, CY, Nadua, K., Hui Tan, NW, & Thoon, KC (2020). A well infant with coronavirus disease 2019 with high viral load. Clinical Infectious Diseases, 71(15), 847–849. https://doi.org/10.1093/cid/ciaa201
Ministry of Health, R. (2021). Latest Situation of the Development of Coronavirus Disease (COVID-19) January 21, 2021. https://infectionemerging.kemkes.go.id/situasi-sepsi-emerging/situasi-terkini-perkembangan-coronavirus-disease-covid-19-21-januari- 2021
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, KSM, Lau, EHY, Wong, JY, Xing, X ., Xiang, N., Wu, Y., Li, C., Chen, Q., Li, D., Liu, T., Zhao, J., Liu, M., … Feng, Z. (2020) . Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine, 382(13), 1199–1207. https://doi.org/10.1056/nejmoa2001316
Li, X., Geng, M., Peng, Y., Meng, L., & Lu, S. (2020). Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis, 10(2), 102–108. https://doi.org/10.1016/j.jpha.2020.03.001
Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. Clinical Chemistry and Laboratory Medicine, 58(7), 1131–1134. https://doi.org/10.1515/cclm-2020-0198
Liu, Jing, Li, S., Liu, J., Liang, B., Wang, X., Wang, H., Li, W., Tong, Q., Yi, J., Zhao, L., Xiong , L., Guo, C., Tian, J., Luo, J., Yao, J., Pang, R., Shen, H., Peng, C., Liu, T., Zhang, Q., … Zheng, X. (2020). Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine, 55. https://doi.org/10.1016/j.ebiom.2020.102763
Liu, K., Fang, YY, Deng, Y., Liu, W., Wang, MF, Ma, JP, Xiao, W., Wang, YN, Zhong, MH, Li, CH, Li, GC, & Liu , HG (2020). Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chinese Medical Journal, 133(9), 1025–1031. https://doi.org/10.1097/CM9.0000000000000744
Liu, Y., Gayle, AA, Wilder-Smith, A., & Rocklöv, J. (2020). The reproductive number of COVID-19 is higher compared to SARS coronavirus. Journal of Travel Medicine, 27(2), 1–4. https://doi.org/10.1093/jtm/taaa021
Longato, E., Di Camillo, B., Sparacino, G., Gubian, L., Avogaro, A., & Fadini, GP (2020). Cardiovascular outcomes of type 2 diabetic patients treated with SGLT-2 inhibitors versus GLP-1 receptor agonists in real-life. BMJ Open Diabetes Research & Care, 8(1). https://doi.org/10.1136/bmjdrc-2020-001451
Mantovani, A., Byrne, CD, & Zheng, M. (2020). Since January 2020 Elsevier has created a COVID-19 resource center with free information in English and Mandarin on the novel coronavirus COVID-19 . The COVID-19 resource center is hosted on Elsevier Connect, the company's public news and information. January.
Minuljo, TT, Anindita, YPC, Seno, HNH, Pemayun, TGD, & Sofro, MAU (2020). Characteristics and Outcomes of COVID-19 Patients with DM at the Dr. Kariadi (Patient review period March-July 2020). Medica Hospitalia : Journal of Clinical Medicine, 7(1A), 150–158. https://doi.org/10.36408/mhjcm.v7i1a.473
Ong, SWX, Tan, YK, Chia, PY, Lee, TH, Ng, OT, Wong, MSY, & Marimuthu, K. (2020). Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from a Symptomatic Patient. JAMA - Journal of the American Medical Association, 323(16), 1610–1612. https://doi.org/10.1001/jama.2020.3227
Padmanabhan Srivatsan. (2020). Potential dual therapeutic approach against SARS-CoV-2/COVID-19 with Nitazoxanide and Hydroxychloroquine. Preprint, March. https://doi.org/10.13140/RG.2.2.28124.74882
Indonesian Lung Doctors Association (PDPI). (2020). Covid-19 Pneumonia: Diagnosis & Management in Indonesia. Indonesian Lung Doctors Association.
Poggiali Erika, Alessandro Dacrema, Davide Bastoni, Valentina Tinelli, Elena Demichele, Pau Mateo Ramos, Teodoro Marcianò, Matteo Silva, Andrea Vercelli, and AM (2009). Letters to the Editor. Tumori Journal, 95(1), 131–131. https://doi.org/10.1177/030089160909500127
Richardson, S., Hirsch, JS, Narasimhan, M., Crawford, JM, McGinn, T., Davidson, KW, Barnaby, DP, Becker, LB, Chelico, JD, Cohen, SL, Cookingham, J., Coppa, K., Diefenbach, MA, Dominello, AJ, Duer-Hefele, J., Falzon, L., Gitlin, J., Hajizadeh, N., Harvin, TG, … Zanos, TP (2020). Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalized with COVID-19 in the New York City Area. JAMA - Journal of the American Medical Association, 323(20), 2052–2059. https://doi.org/10.1001/jama.2020.6775
Riedel, S,, Morse, S,, Mietzner, T,, Miller, SJ, Melnick, & A. (2019). Medical Microbiology (28th ed.). McGraw-Hill Education/Medical.
Rothan, HA, & Byrareddy, SN (2020). Since January 2020 Elsevier has created a COVID-19 resource center with free information in English and Mandarin on the novel coronavirus COVID-19 . The COVID-19 resource center is hosted on Elsevier Connect, the company's public news and information. January.
Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Thiel, V., Janke, C., Guggemos, W., Seilmaier, M., Drosten, C., Vollmar, P., Zwirglmaier, K., Zange, S., Wölfel, R., & Hoelscher, M. (2020). Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. New England Journal of Medicine, 382(10), 970–971. https://doi.org/10.1056/nejmc2001468
Salehi, S., Abedi, A., Balakrishnan, S., & Gholamrezanezhad, A. (2020). Coronavirus disease 2019 (COVID-19): A systematic review of imaging findings in 919 patients. American Journal of Roentgenology, 215(1), 87–93. https://doi.org/10.2214/AJR.20.23034
Shen, C., Wang, Z., Zhao, F., Yang, Y., Li, J., Yuan, J., Wang, F., Li, D., Yang, M., Xing, L., Wei, J., Xiao, H., Yang, Y., Qu, J., Qing, L., Chen, L., Xu, Z., Peng, L., Li, Y., … Liu, L. (2020). Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma. JAMA - Journal of the American Medical Association, 323(16), 1582–1589. https://doi.org/10.1001/jama.2020.4783
Shi, H., Han, X., Jiang, N., Cao, Y., Alwalid, O., Gu, J., Fan, Y., & Zheng, C. (2020). Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. The Lancet Infectious Diseases, 20(4), 425–434. https://doi.org/10.1016/S1473-3099(20)30086-4
Society of Critical Care Medicine. (2020). Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). https://www.sccm.org/SurvivingSepsisCampaign/Guidelines/COVID-19
Sugiyono. (2017). Research Methods Quantitative, Qualitative and R&D. Alphabet.
Sulantari, S., & Hariadi, W. (2020). Analysis of Survival Time to Recover Covid-19 Patients in Banyuwangi Regency. Transformation: Journal of Mathematics and Mathematics Education, 4(2), 375–386. https://doi.org/10.36526/tr.v4i2.1001
US National Library of Medicine. (2020). Safety and Immunogenicity Study of 2019-nCoV Vaccine (mRNA-1273) to Prevent SARS-CoV-2 Infection. https://clinicaltrials.gov/ct2/show/NCT04283461 Journal
Main, S. (2005). Understanding the Phenomenon of Hospital Patient Satisfaction. Health Management, 09(1), 1–7.
Valderas, JM, Starfi, B., & Sibbald, B. (2009). Understanding Health and Health Services. Annals Of Family Medicine, 357–363. https://doi.org/10.1370/afm.983.Martin
van Doremalen, N., Bushmaker, T., Morris, DH, Holbrook, MG, Gamble, A., Williamson, BN, Tamin, A., Harcourt, JL, Thornburg, NJ, Gerber, SI, Lloyd-Smith, JO , de Wit, E., & Munster, VJ (2020). Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to SARS-CoV-1. MedRxiv. https://doi.org/10.1101/2020.03.09.20033217
Wang, C., Li, W., Drabek, D., Okba, NMA, van Haperen, R., Osterhaus, ADME, van Kuppeveld, FJM, Haagmans, BL, Grosveld, F., & Bosch, BJ (2020) . A human monoclonal antibody blocking SARS-CoV-2 infection. Nature Communications, 11(1), 1–6. https://doi.org/10.1038/s41467-020-16256-y
Wang, F., Nie, J., Wang, H., Zhao, Q., Xiong, Y., Deng, L., Song, S., Ma, Z., Mo, P., & Zhang, Y. (2020). Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia. The Journal of Infectious Diseases, 221(11), 1762–1769. https://doi.org/10.1093/infdis/jiaa150
Wang, H., Yang, P., Liu, K., Guo, F., Zhang, Y., Zhang, G., & Jiang, C. (2008). SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway. Cell Research, 18(2), 290–301. https://doi.org/10.1038/cr.2008.15
Wang, Z., Qiang, W., & Ke, H. (2020). A Handbook of 2019-nCoV Pneumonia Control and Prevention. Hubei Science and Technology Press, 1–108.
WHO. (2020a). Advice on the use of masks in the community, during home care, and in health care settings in the context of COVID-19.
WHO. (2020b). Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected.
WHO. (2020c). Coronavirus disease 2019 (COVID-19) Situation Report - 51.
WHO. (2020d). Coronavirus disease 2019 (COVID-19) Situation Report – 70. World Health Organization. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200330-sitrep-70-covid-19.pdf?sfvrsn=7e0fe3f8_2
WHO. (2020e). Coronavirus disease 2019 (COVID-19) Situation Report – 42. World Health Organization. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200302-sitrep-42-covid-19. pdf?sfvrsn=224c1add_2.
WHO. (2020f). Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected.
WHO. (2020g). Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases.
Wu, Z., & McGoogan, JM (2020). Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA - Journal of the American Medical Association, 323(13), 1239–1242. https://doi.org/10.1001/jama.2020.2648 Yan Gabriel, Chun Kiat Lee, Lawrence TM Lam, Benedict Yan, Ying Xian Chua, Anita YN Lim, Kee Fong Phang, Guan Sen Kew, Hazel Teng, Chin Hong Ngai, Li Lin, Rui Min Foo, Surinder Pada, LCN (2020). Covert COVID-19 and false-positive dengue serology in Singapore. The Lancet, January, 19–20.
Yonata, A., Science, B., Dalam, P., Medicine, F., & Lampung, U. (2016). Effect of Comorbidity on the Occurrence of Gram Negative MDR Bacteremia in Hospitalized Patients The Effect of Comorbidity on MDR Gram Negative Bacteremia among Hospitalized Patients. 1, 211–214.
Zhang, H., Penninger, JM, Li, Y., Zhong, N., & Slutsky, USA (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Medicine, 46(4), 586–590. https://doi.org/10.1007/s00134-020-05985-9
Zhang, L., Yan, X., Fan, Q., Liu, H., Liu, X., Liu, Z., & Zhang, Z. (2020). D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. Journal of Thrombosis and Haemostasis, 18(6), 1324–1329. https://doi.org/10.1111/jth.14859
Zou Lirong, Feng Ruan, Mingxing Huang, Lijun Liang, Huitao Huang, Zhongsi Hong, Jianxiang Yu, Min Kang, Yingchao Song, Jinyu Xia, Qianfang Guo, Tie Song, JH (2020). An Animal Model of Inhaled Vitamin E Acetate and EVALI-like Lung Injury. New England Journal of Medicine, 382(12), 1175–1177. https://doi.org/10.1056/nejmc2000231
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