The Effectiveness of X Herbal Medicine On The Reducing Blood Sugar In A Diabetic Mice Model
DOI:
https://doi.org/10.51601/ijhp.v5i4.494Abstract
The prevalence of Diabetes Mellitus in Indonesia is estimated to reach 21.3 million people by 2030. Treatment with oral antidiabetic drugs carries the risk of myocardial infarction and congestive heart failure, while modern therapy of NIDDM has adverse side effects. WHO recommends researching traditional methods, especially plants with hypoglycemic effects. Efficacy claims in herbal medicines, especially herbal medicines, are rarely reported, so it is necessary to test antidiabetic activity to ensure their use. To determine the antidiabetic activity of herbal medicine product X on blood sugar levels in aloxane-induced mice (Mus Musculus), determine the most effective dose, and determine the decrease in GDP after the administration of herbal medicine X on days 7 and 14. Experimental research uses male mice (Mus Musculus) as test animals. Blood glucose levels were measured before and after treatment, with a negative control of CMC-Na of 0.5% and a positive control of glibenclamide of 0.65mg/Kg BB. The optimal dose of herbal product X is determined by a ratio of doses of 52 mg/KgBB, 104 mg/KgBB, and 156 mg/KgBB for 7 to 14 days. Herbal Medicine X at doses of 52mg/KgBB, 104mg/KgBB, and 156mg/KgBB succeeded in reducing aloxan-induced blood sugar levels in mice. The dose of 156mg/KgBB was found to be the optimal dose based on the Mann-Whitney test with Sig<0.05. The most significant decline on day 14 was based on the Kruskal Wallis test with Sig<0.05. Herbal Medicine X was effective in lowering blood sugar levels in mice, with an optimal dose of 156mg/Kg BB and a significant decrease on day 14.
Downloads
References
World Health Organization, “Classification of Diabetes Mellitus 2019,” Geneva, 2019.
International Diabetes Federation (IDF), IDF Diabetes Atlas (9th ed.). Brussels, Belgium: International Diabetes Federation, 2019.
International Diabetes Federation (IDF), IDF Diabetes Atlas (10th ed.). Brussels, Belgium: International Diabetes Federation, 2021.
P. Sukardiman, H. Poerwono, and L. Arifianti, “Pengembangan Obat Herbal Fitofarmaka Antidiabetes dari Campuran Ekstrak Herba Sambiloto (Andrographis Paniculata Nees) dan Ekstrak Biji Mahoni (Swietenia Mahagoni Jacq),” Lembaga Penelitian Universitas Airlangga, Surabaya, 2018.
A. Dalimunthe, “Interaksi Sambiloto (andrographis paniculata),” J. Ilm., 2009.
C. P. H. Anugrahini and A. S. Wahyuni, “Narrative Review: Aktivitas Antidiabetes Tanaman Tradisional Di Pulau Jawa,” Pharmacon J. Farm. Indones., pp. 120–131, 2021.
M. Holt, S. N. Baile, and M. Friswe, “Consumption Behaviour among Patients with Diabetes to Complementary and Alternative Medicine in Amerika: Systematic Review,” Inter J Basic Clin Stud, vol. 2, pp. 16–30, 2013.
N. N. Rahmat, D. Hartono, and N. Laili, “Persepsi dan Perilaku Konsumsi Obat Herbal Penderita Diabetes Mellitus Tipe 2 di Desa Pesisir Kecamatan Gending Kabupaten Probolinggo,” J. Nurs. Care Biomol., vol. 5, no. 1, pp. 41–48, 2020, doi: 10.32700/jnc.v5i1.178.
D. F. Hamzah, “Analisis Penggunaan Obat Herbal Pasien Diabetes Mellitus Tipe Ii Di Kota Langsa,” JUMANTIK (Jurnal Ilm. Penelit. Kesehatan), vol. 4, no. 2, pp. 168–177, 2019, doi: 10.30829/jumantik.v4i2.5057.
H. Jangid, S. Chaturvedi, and M. P. Khinchi, “An Overview on Diabetis Mellitus,” Asian J. Pharm. Res. Dev., vol. 5, no. 3, pp. 1–11, 2017.
L. K. Nguma, “Health Seeking and Health Related Behaviour for Type 2 Diabetes Mellitus among Adults in an Urban Community in Tanzania,” University of Otago, 2010.
L. Lopez, W. Chang, and V. Maro, “Complementary medicine practices among diabetics in Northern Tanzania: An ethnomedical survey,” Complement. Altern. Med., vol. 1, no. 1, p. 282, 2017.
S. Saryono, Metodologi Penelitian Kesehatan: penuntun praktis bagi pemula. Yogyakarta: Mitra Cendikia Press, 2011.
M. Ni’am, R. K. Saputri, and N. Februyani, “Standarisasi Parameter Spesifik dan Non-Spesifik Ekstrak Daun Binahong Merah (Anredera cordifolia) dengan Perbedaan Metode Ekstraksi,” Indones. J. Heal. Sci., vol. 3, no. 2, pp. 431–437, 2023, doi: 10.54957/ijhs.v3i2a.564kalau.
Kementerian Kesehatan Republik Indonesia, Farmakope Herbal Indonesia: Suplemen 3, 1st ed. Jakarta: Direktorat Jenderal Pelayanan Kefarmasian dan Alat Kesehatan, Kementerian Kesehatan Republik Indonesia, 2013.
M. S. Dahlan, Statistik untuk Kedokteran dan Kesehatan: Deskriptif, Bivariat dan Multivariat, Dilengkapi dengan Menggunakan SPSS. Jakarta: Salemba Medika, 2014.
P. Aprillia and C. I. N. H. Safitri, “Uji Aktivitas Antidiabetes Kombinasi Ekstrak Herba Sambiloto dan Daun Sirih Hijau pada Mencit,” Pros. SNPBS (Seminar Nas. Pendidik. Biol. dan Saintek), 2020, doi: https://proceedings.ums.ac.id/snpbs/article/view/842.
Q. Aini, S. Suwarniati, and I. Mirza, “Phytochemical Screening of Methanol Extract of Jamblang (Syzygium cumini L.) As Antidiabetic,” J. Biol. sains dan kependidikan, vol. 2, no. 2, 2022, doi: 10.37598/biosainsdik.v2i2.1485.
Q. Aini, S. Suwarniati, and I. Mirza, “Phytochemical Screening of Methanol Extract of Jamblang (Syzygium cumini L.) As Antidiabetic,” J. Biol. sains dan kependidikan, vol. 2, no. 2, 2022, doi: 10.37598/biosainsdik.v2i2.1485.
R. Puspitasari, “Uji efek antidiabetes mellitus tipe II kombinasi madu (Mel depuratum) dan ekstrak daun jati belanda (Guazuma ulmifolia Lamk.) terhadap mencit jantan galur Swiss Webster,” Universitas Al-Ghifari, 2021.
R. Puspitasari, “Uji efek antidiabetes mellitus tipe II kombinasi madu (Mel depuratum) dan ekstrak daun jati belanda (Guazuma ulmifolia Lamk.) terhadap mencit jantan galur Swiss Webster,” Universitas Al-Ghifari, 2021.
A. Agustira, I. Darwis, and D. Isti angraini, “Tanaman sambung nyawa (Gynura procumbens) sebagai antihiperglikemi,” Med. Prof. J. Lampung, vol. 9, no. 2, pp. 240–244, 2019, doi: 10.53089/medula.v9i2.265.
A. Agustira, I. Darwis, and D. I. Angraini, “Tanaman sambung nyawa (Gynura procumbens) sebagai antihiperglikemi,” Med. Prof. J. Lampung, vol. 9, no. 2, 2019, doi: https://doi.org/10.24912/jssh.v1i1.24544213.
E. R. Yuslianti, B. M. Bachtiar, D. F. Suniarti, and A. B. Sutjiatmo, “Natural Products Pharmaceutical Standardization Towards Phytopharmaca for Indonesian Traditional Medicine Development,” Dentika Dent. J., vol. 19, no. 2, pp. 179–185, 2016, doi: 10.32734/dentika.v19i2.463.
M. Kenning, A. Puchert, and E. Salzsieder, “System accuracy evaluation of blood glucose monitoring systems: comparison of four devices for personal use pursuant to ISO and ADA guidelines,” J. Diabetes Sci. Technol., vol. 15, no. 5, pp. 1202–1203, 2021, doi: 10.1177/19322968211011185.
I. K. D. I. Muliawan, “Efek Pemberian Kombinasi Jus Aloe Vera dan Glibenklamid terhadap Penurunan Kadar Glukosa Darah pada Model Tikus Diabetes yang Diinduksi dengan Streptozotosin dan Nikotinamid,” Intisari Sains Medis, vol. 10, no. 2, pp. 527–531, 2019, doi: 10.15562/ism.v10i2.532.
J. T. Barr, T. B. Tran, B. M. Rock, J. L. Wahlstrom, and U. P. Dahal, “Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?,” Drug Metab. Dispos., vol. 48, no. 8, pp. 613–621, 2020, doi: 10.1124/dmd.120.090621.
F. T. B. Aminah and N. Qomariyah, “Efek Antihiperglikemik Ekstrak Daun Ceremai (Phyllanthus acidus) pada Mencit (Mus musculus) Diabetes Mellitus Tipe II,” LenteraBio Berk. Ilm. Biol., vol. 12, no. 3, pp. 363–370, 2023, doi: 10.26740/lenterabio.v12n3.p363-370.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Purwaeni Purwaeni, Nurbaiti Fentiani Siahaan, Meilinda Windy Astuty
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
