Idiopathic Pulmonary Fibrosis Mimics Pulmonary Malignancy: A Case Report

Authors

  • Ketut Wiswa Wikrama Duta Wacana Christian University, Yogyakarta, Indonesia
  • Carolus Boromeus Tabuni Bethesda Hospital, Yogyakarta, Indonesia
  • Ananda Digdoyo Duta Wacana Christian University, Yogyakarta, Indonesia
  • Putu Nanda Pratama Putra Duta Wacana Christian University, Yogyakarta, Indonesia
  • Petra Gusti Parikesit Duta Wacana Christian University, Yogyakarta, Indonesia
  • Sutaryanu Darmoredjo Bethesda Hospital, Yogyakarta, Indonesia

DOI:

https://doi.org/10.51601/ijhp.v5i4.508

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by extracellular matrix accumulation, often mimicking pulmonary malignancy in clinical and radiological aspects. Early and accurate diagnosis remains a challenge. Objective: To report a case of IPF presenting with hemoptysis and radiological features suggestive of malignancy, highlighting diagnostic complexities. Methods: This qualitative case study involved detailed clinical, radiological, and histopathological examination of a 60-year-old female patient. Data were collected through medical records, CT imaging, biopsies, and interviews. Thematic content analysis ensured rigorous interpretation. Results: Radiologic findings indicated suspicious masses bilaterally, yet histopathology confirmed pulmonary fibrosis without malignancy. This underscores the overlap in presentation and diagnostic ambiguity between IPF and lung cancer. Conclusion: Multimodal diagnostic approaches combining imaging and biopsy are essential to distinguish IPF from malignancy and to guide treatment. Increased clinician awareness and multidisciplinary collaboration enhance diagnostic accuracy and prognosis. Further research with larger samples is recommended to improve non-invasive diagnostic tools.

Downloads

Download data is not yet available.

References

Armstrong, J., Smith, R., & Gonzalez, F. (2021). Clinical challenges in differential diagnosis of pulmonary ma-lignancies and interstitial lung diseases. Journal of Pulmonary Medicine, 15(3), 210–219.

Creswell, J. W. (2021). Research design: Qualitative, quantitative, and mixed methods approaches (5th ed.). SAGE Publications.

Emzir. (2021). Qualitative research methodology: Data analysis and the use of triangulation. Prenadamedia Group.

Hadi, S. (2022). Ethical considerations in clinical case study research: A guide for health researchers. Health Science Journal, 28(2), 145–154.https://doi.org/10.5678/hsj.2022.02802

Huang, Y., Li, Y., & Wang, F. (2022). Radiological patterns of idiopathic pulmonary fibrosis: Diagnostic chal-lenges and differential diagnosis. European Respiratory Journal, 60(1), 2102436.https://doi.org/10.1183/13993003.02436-2021

Hutchinson, J., Fogarty, A., Hubbard, R., & McKeever, T. (2023). Global epidemiology of idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 207(2), 123–130.

Juarez, MM, Chan, AL, Norris, AG, Morrissey, BM, & Albertson, TE (2015). Acute exacerbation of idiopathic pulmonary fibrosis—A review of current and novel pharmacotherapies. Journal of Thoracic Disease, 7(13), 2255–2268.https://doi.org/10.3978/j.issn.2072-1439.2015.01.17

Lee, W. K., Lau, E. W. F., Chin, K., Sedlaczek, O., & Steinke, K. (2013). Modern diagnostic and therapeutic interventional radiology in lung cancer. Journal of Thoracic Disease, 5(Suppl 5), S574–S590.

Lederer, D. J., & Martinez, F. J. (2018). Idiopathic pulmonary fibrosis. New England Journal of Medicine, 378(19), 1811–1823.https://doi.org/10.1056/NEJMra1705751

Martinez, F.J., King, T.E., & Raghu, G. (2022). Current understanding and management of idiopathic pulmonary fibrosis. Lancet Respiratory Medicine, 10(8), 747–757.https://doi.org/10.1016/S2213-2600(22)00126-5

Pathology, P., & Nurdin, W. (2015). Histopathological aspects of interstitial lung disease. Faculty of Medicine, University of Indonesia.

Quinn, C., Wisse, A., & Manns, S. T. (2019). Clinical course and management of idiopathic pulmonary fibrosis. BMC Pulmonary Medicine, 19(1), 54.https://doi.org/10.1186/s40248-019-0197-0

Raghu, G., & Richeldi, L. (2017). Current approaches to the management of idiopathic pulmonary fibrosis. Res-piratory Medicine, 123, 69–78.https://doi.org/10.1016/j.rmed.2017.05.017

Raghu, G., Rochwerg, B., Zhang, Y., Garcia, C., Azuma, A., Behr, J., Brozek, J., Collard, H.R., Cox, G., & Cottin, V. (2022). An official ATS/ERS/JRS/ALAT clinical practice guideline: Treatment of idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 205(7), e18–e47.

Sudaryono, A. (2023). Qualitative data analysis using thematic methods: Theory and its application. Media Akademia Press.

Sugiyono. (2022). Quantitative, qualitative and R&D research methods. Alfabeta.

Tosi, D., Mazzara, C., Bozzetti, C., & Dore, R. (2019). CT-guided fine-needle aspiration biopsy of solitary pul-monary nodules under 15 mm in diameter: Time for an afterthought? Journal of Thoracic Disease, 11(3), 724–731.https://doi.org/10.21037/jtd.2019.02.58

Wells, A.U., Brown, K.K., Flaherty, K.R., & Kolb, M. (2021). What's new in idiopathic pulmonary fibrosis. Eu-ropean Respiratory Review, 30(159), 210182.https://doi.org/10.1183/16000617.0182-2021.

Downloads

Published

2025-12-24

How to Cite

Wiswa Wikrama, K., Boromeus Tabuni, C., Digdoyo, A., Nanda Pratama Putra, P., Gusti Parikesit, P., & Darmoredjo, S. (2025). Idiopathic Pulmonary Fibrosis Mimics Pulmonary Malignancy: A Case Report. International Journal of Health and Pharmaceutical (IJHP), 5(4), 48–51. https://doi.org/10.51601/ijhp.v5i4.508