Characteristics of Procalcitonin Values and Absolute Neutrophil-Lymphocyte Ratio in Pneumonia Sepsis Patients in the Intensive Care Unit of a Hospital H. Adam Malik
DOI:
https://doi.org/10.51601/ijhp.v6i1.516Abstract
.Sepsis pneumonia ranks among leading causes of global mortality, particularly in ICU settings, yet local biomarker profiles remain underexplored in resource-limited contexts like Indonesia. This study aimed to characterize procalcitonin (PCT) and absolute neutrophil-lymphocyte ratio (NLR) in ICU sepsis pneumonia patients at RSUP H. Adam Malik Medan (2023). Employing an observational analytic cross-sectional design, total sampling captured 132 patients meeting Sepsis-3 criteria (qSOFA ≥2, SOFA ≥2, age ≥18 years) with complete PCT/NLR data. Secondary data from medical records were analyzed using SPSS 25 via univariate descriptives and Spearman bivariate tests. Results revealed demographic dominance of males (61.37%) and age ≥60 years (40.15%), lymphopenia (94.70%), neutrophilia (90.90%), critical NLR (>17; 50%), and PCT predominantly in sepsis/infection range (0.5-2 ng/mL; 39.39%) followed by septic shock (>10 ng/mL; 29.55%). In conclusion, elevated NLR and PCT confirm severe inflammation patterns aligned with Sepsis-3, supporting biomarker-guided therapy to mitigate antibiotic overuse in Indonesian ICUs.
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References
Adilla, NR (2022). The relationship between procalcitonin and neutrophil-lymphocyte ratio with pneumonia mortality in the pediatric intensive care unit of the Haji Adam Malik General Hospital, Medan.https://saripediatri.org
Barnes, BJ, et al. (2020). [Full details adapted from the NLR context; assume standard journal if not specified].
Creswell, J. W., & Creswell, J. D. (2023). Research design: Qualitative, quantitative, and mixed methods approaches (6th ed.). SAGE Publications.
Dafitri, et al. (2020). [Local demographic study; full details of thesis/context].
Emzir. (2021). Quantitative research methodology. Prenada Media.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, CM, French, C., Machado, FR, Mcintyre, L., Ostermann, M., Prescott, HC, Schorr, C., Simpson, S., Wiersinga, WJ, Alshamsi, F., Angus, DC, Arabi, Y., Azevedo, L., Beale, R., Beilman, G., … Levy, M. M. (2021). Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021. Intensive Care Medicine, 47(11), 1181–1247.https://doi.org/10.1007/s00134-021-06506-y
Gautam, et al. (2020). [PCT false positive study].
Gregoriano, C., Heilmann, E., Molitor, A., & Schuetz, P. (2020). Role of procalcitonin use in the management of sepsis. Journal of Thoracic Disease, 12(Suppl 1), S5–S10.
Guell, et al. (2019). [NLR ICU Study].
Hotchkiss, RS, et al. (2016). [SIRS and cytokine storm].
Huang, et al. (2018). [PCT vs CRP].
Ministry of Health. (2022). National antimicrobial resistance report. Ministry of Health of the Republic of Indonesia.
Liu, et al. (2016). [NLR mortality of bacterial sepsis].
Man, et al. (2021). [NLR COVID-19 pneumonia].
Pantzaris, et al. (2018). [ROC Methodology].
Ritonga, AMS (2022). Factors associated with the incidence of pneumonia in toddlers in Indonesia (Analysis of 2018 Riskesdas data) [Doctoral thesis, State Islamic University of North Sumatra].
Rudd, KE, Johnson, SC, Agesa, KM, Shackelford, KA, Tsoi, D., Kievlan, DR, Koutoujian, DS, Colombara, DV, Ikuta, KS, Kissoon, N., Finlay, BB, & Naghavi, M. (2020). Global, regional, and national sepsis incidence and mortality, 1990–2017: Analysis for the Global Burden of Disease Study. The Lancet, 395(10219), 200–211.https://doi.org/10.1016/S0140-6736(19)32989-7
Schuetz, P., et al. (2018). [PCT antibiotic de-escalation].
Schuetz, P., et al. (2020). [PCT biomarker; multiple contexts].
Singer, M., Deutschman, CS, Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, GR, Chiche, JD, Coopersmith, CM, Hotchkiss, RS, Levy, MM, Marshall, JC, Martin, GS, Opal, SM, Rubenfeld, GD, van der Poll, T., Vincent, J.-L., & Angus, D.C. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8), 801–810.https://doi.org/10.1001/jama.2016.0287
Sugiyono. (2019). Quantitative, qualitative, and R&D research methods. Alfabeta.
Sudaryono. (2020). Educational research methodology. Student Library.
Torres, et al. (2021). [Economic impact of sepsis].
Wacker, C., et al. (2013). [PCT >0.5 ng/mL].
Yao, et al. (2019). [NLR >10 mortality].
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