Association between Mean Platelet Volume (MPV) and Mayor Cardiovascular Incidence among Inpatient Acute Myocardial Infraction with ST-Elevation
DOI:
https://doi.org/10.51601/ijhp.v2i2.53Abstract
MPV value is an index of platelet associated with platelet activity. A larger platelet size shows a hyper-reactive platelet and accelerates thrombus formation with coronary circulation, leading to major cardiovascular events. Hence, this study was designed to investigate the relationship between MPV value and each type of major cardiovascular event in General Hospital Haji Adam Malik. This study was observational research with a cross-sectional design in General Hospital Haji Adam Malik in October 2014-January 2015 among sixty-nine ACS inpatients with ST-Elevation. The evaluated major cardiovascular events were death, heart failure, arrhythmia, and cardiogenic shock. The average MPV value of ACS patients with heart failure, cardiogenic shock, arrhythmia, death, and all major cardiovascular events was 10.08 fL, 10.40 fL, 10.00 fL, 9.76 fL, and 10.00 fL, respectively. Either major cardiovascular event did not show any significant difference in the average MPV value due to these P-Values > 0.05. Hence, it can be concluded that the MPV value cannot be used to predict the incidence of either major cardiovascular event in ACS patients.
References
World Health Organization, ‘Noncommunicable Diseases’, World Health Organization, 2021. .
P. Kabo, Bagaimana Menggunakan Obat-Obat Kardiovasular Secara Rasional. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia, 2012.
S. S. Virani et al., Heart disease and stroke statistics—2020 update: A report from the American Heart Association. New York: American Heart Association, 2020.
World Health Organization, ‘Cardiovascular Diseases (CVDs)’, World Health Organization, 2021. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (accessed Dec. 01, 2021).
Kementerian Kesehatan Republik Indonesia, Hasil Utama Riset Kesehata Dasar (RISKESDAS) tahun 2018 [Chief Results of Basic Health Research (RISKESDAS) in 2018]. Jakarta: Kementerian Kesehatan RI, 2019.
L. I. Rilantono, Penyakit Jantung Koroner dalam Lima Rahasia Penyakit Kardiovaskular. Jakarta: Badan Penerbit FK UI, 2013.
A. Eisen, T. Bental, A. Assali, R. Kornowski, and E. I. Lev, ‘Mean platelet volume as a predictor for long-term outcome after percutaneous coronary intervention’, J. Thromb. Thrombolysis, vol. 36, no. 4, pp. 469–474, 2013, doi: 10.1007/s11239-013-0876-1.
Y. Nozari, M. Parsa, A. Jalali, H. Ariannejad, and A. Shafiee, ‘Mean platelet volume and major adverse cardiac events following percutaneous coronary intervention’, Arch. Iran. Med., vol. 22, no. 4, pp. 198–203, 2019.
H. Mumpuni, H. Hariawan, and L. Krisdinarti, ‘Association Between Mean Platelet Volume (MPV) with Major Adverse Cardiovascular Events in Acute Coronary Syndrome during Hospitalization’, ACI (Acta Cardiol. Indones., vol. 2, no. 2, pp. 47–55, 2016, doi: 10.22146/aci.22602.
X. P. Sun, B. Y. Li, J. Li, W. W. Zhu, and Q. Hua, ‘Impact of Mean Platelet Volume on Long-Term Mortality in Chinese Patients with ST-Elevation Myocardial Infarction’, Sci. Rep., vol. 6, no. 21350, pp. 1–5, 2016, doi: 10.1038/srep21350.
Y. Wang et al., ‘Risk Factors Associated with Major Cardiovascular Events 1 Year after Acute Myocardial Infarction’, JAMA Netw. Open, vol. 1, no. 4, pp. 1–13, 2018, doi: 10.1001/jamanetworkopen.2018.1079.
T. R. Einarson, A. Acs, C. Ludwig, and U. H. Panton, ‘Prevalence of Cardiovascular Disease in Type 2 Diabetes: A Systematic Literature Review of Scientific Evidence from Across the World in 2007-2017’, Cardiovasc. Diabetol., vol. 17, no. 1, pp. 1–19, 2018, doi: 10.1186/s12933-018-0728-6.
R. Pal, R. Bagarhatta, S. Gulati, M. Rathore, and N. Sharma, ‘Mean platelet volume in patients with acute coronary syndromes: A supportive diagnostic predictor’, J. Clin. Diagnostic Res., vol. 8, no. 8, pp. 10–13, 2014, doi: 10.7860/JCDR/2014/8394.4650.
W. E. O. Elradi, E. I. Abdallah, E. E. Diab, O. M. Ahmed, A. A. M. Alkhanjaf, and E. E. Hassan, ‘MPV as Prognostic Factor for Patients with Coronary Artery Diseases in Sudan’, Int. J. Sci. Res., vol. 9, no. 11, pp. 150–153, 2020, doi: 10.21275/SR201028140258.
K. T. Ulutas et al., ‘Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: A marker for atherosclerosis?’, Int. J. Clin. Exp. Med., vol. 7, no. 4, pp. 955–961, 2014.
E. Indriastuti, Y. Hernaningsih, Y. N. Indrasari, and Andrianto, ‘Immature Platelet Fraction as a Potential Marker to Differentiate Types of Acute Coronary Syndrome’, Indones. J. Clin. Pathol. Med. Lab., vol. 27, no. 1, pp. 16–21, 2020.
Y. Nozari, M. Bahrehmand, S. K. Hosseini, M. Mahmoodoan, and A. Sharafi, ‘Mean Platelet Volume as a Predictor of One-Year Major Adverse Cardiac Events Following Elective Percutaneous Coronary Interventions’, J. Tehran Univ. Hear. Cent., vol. 9, no. 2, pp. 64–69, 2014, [Online]. Available: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L373244033%5Cnhttp://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=20082371&id=doi:&atitle=Mean+platelet+volume+as+a+predictor+of+one-year+major+adverse+cardiac+events+following+elective.
C. Tian, J. Song, D. He, J. Wu, Z. Sun, and Z. Sun, ‘Predictive value of mean platelet volume/platelet count for prognosis in acute myocardial infarction’, Int. Heart J., vol. 59, no. 2, pp. 286–292, 2018, doi: 10.1536/ihj.17-212.
A. A. López-Cuenca, A. Tello-Montoliu, V. Roldán, P. Pérez-Berbel, M. Valdés, and F. Marín, ‘Prognostic value of mean platelet volume in patients with non-ST-elevation acute coronary syndrome’, Angiology, vol. 63, no. 4, pp. 241–244, 2012, doi: 10.1177/0003319711413892.
K. Supel, A. Salska, F. Jaskiewicz, M. Kacprzak, and M. Zielinska, ‘Mean platelet volume and its prognostic value in acute coronary syndrome complicated by cardiogenic shock’, Cardiol. J., vol. 20, no. 3, pp. 254–260, 2013, doi: 10.5603/CJ.2013.0070.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Blessdova Fransza A.S.Hutabarat, Harris Hasan, Nizam Zikri Akbar
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
