Incidence Profile of Side Effects of Anti-Tuberculosis Drugs and Adherence To Taking Medication In Tuberculosis Patients At The Sukolilo 1 Health Center
DOI:
https://doi.org/10.51601/ijhp.v6i2.533Abstract
Tuberculosis (TB) is a disease caused by infection with the bacterium Mycobacterium tuberculosis and can be fatal. Long-term TB treatment has the potential to cause side effects, but adherence to medication is still necessary to achieve therapeutic effectiveness, reduce the risk of transmission, and prevent drug resistance. This study aims to determine the relationship between the side effects of anti-TB drugs (OAT) and medication adherence in TB patients at the Sukolilo Community Health Center in Pati. This study used a descriptive observational method with a cross-sectional approach. A total of 100 patients met the inclusion criteria: aged 18–65 years, making outpatient visits during August 2025, having at least two visits with a TB diagnosis, and willing to be research subjects. Respondents with incomplete questionnaires were excluded from this study. The study showed that the majority of patients were aged 61–65 years, male (64.0%), with the highest level of education being elementary school (48.0%), and working as farmers (60.0%). Most patients were married (87.0%) and had a family of four (40.0%). The most common side effect of OAT was joint pain (40.0%), while the least common were burning sensation in the feet and visual disturbances (5.0 each). The level of medication adherence was mostly in the moderate category (96.0%). The results showed no relationship between the side effects of OAT use and medication adherence in tuberculosis patients, with a p-value of 0.521.
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[1]. Agustina, Ella. 2021. "Literature Review of Compliance of Tuberculosis Patients."
[2]. Adam, L. 2020. Knowledge of Pulmonary Tuberculosis Patients on Compliance with Anti-Tuberculosis Drugs. Jambura Health and Sport Journal 2(1): 12–18.
[3]. Afilla Christy, Berly, Ressi Susanti, and Nurmainah Nurmainah. 2022. "The Relationship of Drug Adherence Levels of Tuberculosis Patients to Anti-Tuberculosis Drug (OAT) Side Effects." Journal of Syifa Sciences and Clinical Research 4(1): 484–93.
[4]. Afwansyah, Miftahul, and Haafizah Dania. 2022. "Compliance Level of the Use of Anti-Tuberculosis Drugs in PKU Muhammadiyah Bantul Hospital Using the Pill-Count and MARS Methods." Pharmacy: Scientific Journal of Pharmaceutical Sciences 9(1): 9–17.
[5]. Amining, Fauziah et al. 2021. "The Effect of the Role of Drug Swallowing Supervisors and Anti-Tuberculosis Drug Side Effects on the Cure Rate of Tuberculosis Patients." Preventive: Journal of Public Health 12(2): 386.
[6]. Anisa Rahayu Eka Putri, and Suwendar. 2022. Monitoring Side Effects of Antituberculosis Drugs (OAT) in Category I Tuberculosis Patients at the Bayongbong Health Center, Garut Regency. Bandung Conference Series: Pharmacy 2(2).
[7]. Andira, Besse Putri et al. 2024. "The Relationship of Side Effects of Anti-Tuberculosis Drugs (OAT) with Treatment Compliance in Tuberculosis Patients at the Jongaya Health Center Makassar." Wal'afiat Hospital Journal 5(1): 48–59.
[8]. Absor, Sholihul, Annisa Nurida, Yelvi Levani, and Wichda Shirosa Nerly. 2020. "The Relationship between Education Level and Treatment Compliance of Pulmonary TB Patients in Lamongan Regency in January 2016–December 2018." Medica Arteriana (Med-Art) 2(2): 80.
[9]. Bakri, T. K., Akmal, R., Vonna, A., and Sari, F. 2021. "The Impact of Adverse Drug Reaction Occurrence to Drug Adherence Level: A Cross-Sectional Study in Patients With Tuberculosis." Journal of Clinical Pharmacy 8(2): 105–115.
[10]. Bone, Nur Rahma. 2023. "Systematic Literature Review: Drug Side Effects on Body Health." 7: 31030–34.
[11]. Chandra Mohapatra, G., Khan, J., Nayak, S., and Chandra Mohapatra, D. 2021. "Incidence of Hyperuricemia and Gouty Arthritis in Patients Taking Pyrazinamide for the Treatment of Tuberculosis." 25(6): 324–328.
[12]. Central Java Health Office. 2022. Health Profile of Central Java in 2023. 97–104.
[13]. Pati Regency Health Office. 2023. Pulmonary TB Patient Data. Pati.
[14]. Edi, I. G. M. S. 2020. "Factors Affecting Patient Adherence to Treatment." Scientific Journal of Medicine 1(1): 1–8.
[15]. Imam, F. et al. 2020. "Adverse Drug Reaction Prevalence and Mechanisms of Action of First-Line Anti-Tubercular Drugs." Saudi Pharmaceutical Journal 28(3): 316–324.
[16]. Scientific Journal of Pharmaceutical et al. 2023. "Relationship Between The Incidence Of Side Effects Of Using Anti-Tuberculosis Drugs And Compliance With Taking Medication In Tuberculosis Patients At The Kuwarasan Health Center Kebumen Regency." Journal of Pharmacology 6(2): 56.
[17]. Ministry of Health of the Republic of Indonesia (P2PL). 2020. Find TB Treat Until Cured: Management of Drug-Resistant Tuberculosis in Indonesia.
[18]. Ministry of Health of the Republic of Indonesia. 2023. Report on the 2022 Tuberculosis Control Program. Ministry of Health of the Republic of Indonesia.
[19]. Kristiani, Windilla et al. 2019. "Monitoring Side Effects of Tuberculosis Drugs." : 26–42.
[20]. Kristiani, Windilla et al. 2022. "Monitoring Side Effects of Tuberculosis Drugs." : 26–42.
[21]. Maulitha, F., Fitriani, N., and Rusli, R. 2022. Analysis of Adverse Effects of the Use of Antituberculosis Drugs (OAT) in the Outpatient Installation of BLUD Hospital dr. H. Soemarno Sosroatmo.
[22]. Nabila, nothing. 2023. "Factors Influencing Compliance with Anti-Tuberculosis Medication (OAT) in Patients with Pulmonary Tuberculosis (TB): A Literature Review." Indonesian Health Promotion Publication Media (MPPKI) 6(8): 1478–84.
[23]. Nasichah, S. N. A., and Kristinawati, B. 2024. "The Relationship of Side Effects of Anti-Tuberculosis Drugs and Comorbidity Diseases with Quality of Life in Pulmonary Tuberculosis Patients." Journal of Telenursing (JOTING) 6(1).
[24]. Ningsih, Andi Sri Wahyu, Adam M. Ramadhan, and Dewi Rahmawati. 2022. "A Review of the Literature on the Treatment of Pulmonary Tuberculosis and Side Effects of Antituberculosis Drugs in Indonesia." Proceedings of Mulawarman Pharmaceuticals Conferences 15: 231–41.
[25]. Nisa, Qoirun, Nanang Ruhyana, and Thysa Thysmelia Affandi. 2025. "The Relationship between Age and Treatment Compliance Level on the Recovery of Pulmonary TB Patients at Sidawangi Lung Hospital." Ibn Sina: Journal of Medicine and Health 24(1): 222–31.
[26]. Number, Volume, Nur Rasdianah, Teti Sutriati Tuloli, and Widy Susanti Abdulkadir. 2022. "Study of Side Effects of Antituberculosis Drugs (OAT) in Pulmonary TB Patients." That is why we need to be vigilant.
[27]. Reviono et al. 2014. "Multidrug Resistant Tuberculosis (MDR-TB): An Epidemiological Review and Risk Factors for Side Effects of Anti-Tuberculosis Drugs." Bandung Medical Magazine 46(4): 189–96.
[28]. Salsabilah, K. S., and Afriansya, R. 2024. "Environmental, Educational, and Economic Relations of the Community to the Incidence of Pulmonary TB in Kedungmundu, Semarang City." Borneo Journal of Medical Laboratory Technology 6(2): 621–627.
[29]. Sazali, Mohd Fazeli et al. 2023. "Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Models." Tuberculosis and Respiratory Diseases 86(2): 82–93.
[30]. Solikhah, M. M. et al. 2022. "Overview of Family Support for Pulmonary Tuberculosis Patients in Undergoing Treatment in the Wonogiri District Area." Journal of Advanced Nursing and Health Sciences 3(1): 6–13.
[31]. Sulaiman, Eman, and Al Edy Dawu. 2024. "The Relationship of Side Effects, Family Support and Health Facility Distance to TB Patients' Medication Adherence." 3(3): 276–85.
[32]. Sukarno, Anita et al. 2023. "Relationship of Anti-Tuberculosis Drug (OAT) Side Effects on Treatment Adherence of Pulmonary TB Patients." 8(2): 123–31.
[33]. Axis, Alexis Keya et al. 2021. "Impact of Sputum Sampling Instructional Video on Ziehl-Neelsen Positivity in Tuberculosis Diagnostic Centers." OALib 08(04): 1–14.
[34]. Sunarmi, Sunarmi, and Kurniawaty Kurniawaty. 2022. "Relationship of Pulmonary TB Patients with Tuberculosis Outcomes." Journal of 'Aisyiyah Medika 7(2): 182–87.
[35]. Widiati, B., and Majdi, M. 2021. "Analysis of Factors of Age, Education, Occupation, and Pulmonary Tuberculosis." Journal of Sanitation and Environment 2(2): 173–184.
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