Analysis of The Side Effects of Dots (Directly Observed Treatment Shortcourse) on The Success of Pulmonary Tuberculosis (Tuberculosis) Therapy at Raa Soewondo Pati Hospital
DOI:
https://doi.org/10.51601/ijhp.v6i2.601Abstract
This study aims to analyze the side effects of DOTS on the success of TB therapy. The research was conducted at the RAA Soewondo Pati Hospital using a quantitative descriptive method with a cross-sectional approach. Sampling was carried out using a total sampling technique, and 117 respondents were obtained who met the inclusion and exclusion criteria. Data collection was carried out through a questionnaire of side effects and medication adherence that has been tested for validity and reliability, and supported by patient medical record data. Data analysis includes univariate analysis, and bivariate analysis with Chi-square and Odd Ratio (OR) tests. The results showed that the most common side effects experienced by patients were urine discoloration to red (100%), flu syndrome (29.9%), nausea (18.8%), and no appetite (15.4%). The severity of the majority of side effects was in the mild category (88%). The patient compliance rate was relatively high, namely 92.3% complied in undergoing therapy, and 93.2% of patients were declared successful in completing therapy. The results of bivariate analysis showed that there was a very significant relationship and influence between drug side effects and the success of pulmonary tuberculosis therapy. This is shown by the results of the chi-square test which shows a p-value of 0.000 (p<0.05). And the Odd Ratio (OR) which yields a value of 0.010. Interpretation of this value shows that patients who experience moderate side effects have a 100-fold higher risk of therapy failure.
Downloads
References
[1] A. Dirwan. (2020). STATISTICS Practical Applications For Research (A. Dirwan (ed.); 1st ed.). PT Rajagrafindo Persada.
[2] Aini, L., & Astuti, L. (2020). The relationship between the side effects of anti-tuberculosis drugs (oats) and the role of drug swallowing supervisors (PMO) and treatment adherence in patients with pulmonary tuberculosis (TB). Babylon Science Multi Science Health Scientific Journal, 12(2), 24–34. https://doi.org/10.36729/bi.v12i2.935
[3] Andira, B. P., Dahlia, K., Wiriansya, E. P., Irwan, A. A., & Hamzah, P. N. (2024). The Relationship between Side Effects of Anti-Tuberculosis Drugs (OAT) and Treatment Compliance in Tuberculosis Patients at the Jongaya Health Center Makassar.
[4] Asclepius, J. K. (2024). Treatment Behavior of TB Patients Based on Health Belief Model Theory: Literature Review. Sec. 6, 289–296.
[5] Central Statistics Agency (2024). "Disease Cases by Regency/City and Type of Disease in Central Java Province, 2023." https://jateng.bps.go.id/id/statistics- table/3/ YTA1Q1ptRmhUME pXWTB sQ mQyZzBjVzgwUzB4aVp6MDkjMw==/case-disease-by-district-city-d
[6] Kesehatan, K., & Indonesia, R. (2022). Technical Instructions for Active Monitoring and Management of Drug Side Effects (Active MESO).
[7] Ministry of Health of the Republic of Indonesia (2024)"Ministry of Health Beware of Increasing TB Cases in Indonesia" Ministry of Health of the Republic of Indonesia. https://www.menpan.go.id/site/berita-terkini/berita-daerah/kemenkes-waspadai-kasus-tb-di-indonesia-yang-meningkat
[8] Ministry of Health of the Republic of Indonesia (2025) "Age Category" https://ayosehat.kemkes.go.id/kategori-usia
[9] Lisdawati, V., Banggai, C. E., Radi, T., Rogayah, R., & Murtiani, F. (2017). Monitoring Side Effects of Anti-Tuberculosis Drugs at the TB DOTS Polytechnic RSPI Prof. Dr. . Sulianti Saroso. 5(2), 10–20.
[10] Mar'iyah Khusnul, Z. (2021). The pathophysiology of tuberculosis infectious diseases. http://journal.uin-alauddin.ac.id/index.php/psb
[11] Martini, E., Sarfika, R., Yuliharni, S., Study, P., Nursing, M., Nursing, F., Andalas, U., West, S., Nursing, D., Nursing, F., & West, S. (2024). Overview of the Treatment Compliance Level of Pulmonary TB Patients. 20(2), 108–119.
[12] Murni, D. (2017). This treatment strategy is called DOTS (Directly Observed Treatment Short Course Chemotherapy) the DOTS strategy is a direct supervision of short-term treatment with the requirement of each TB program manager to focus attention in an effort to find p. Journal of Accounting, 11.
[13] Nomor, V., Rasdianah, N., Tuloli, T. S., & Abdulkadir, W. S. (2022). Study of Side Effects of Antituberculosis Drugs (OAT) in Pulmonary TB Patients. 4, 707–717.
[14] Indonesian Pulmonary Doctors Association. (2021). Tuberculosis: Guidelines for Diagnosis and Management in Indonesia. In Indonesian Pulmonary Doctors Association (Vol. 001, Issue 2014).
[15] Retnowati, E., Dikdayani, L., Teguh, A., & Mundriyastutik, Y. (2021). The Relationship of Side Effects of Anti-Tuberculosis Drugs Combination of Package 4 on the Compliance Level of Tuberculosis Patients in the Outpatient Installation of the Jiken Health Center, Blora Regency. Urecol, pp. 1103–1109.
[16] Sani, F. K. (2017). Community and experimental pharmaceutical research methodologies. Dee, 199.
[17] Sari, A. R., Purwanto, H., & Rofi'i, A. Y. A. B. (2022). Overview of the success of treatment in pulmonary tuberculosis patients at the Semanding Health Center. Journal of Nursing Widya Gantari Indonesia, 6(2), 106. https://doi.org/10.52020/jkwgi.v6i2.3374
[18] Seniantara, I. K., Ivana, T., & Gabrilinda, A. Y. (2018). The Effect of Oats (Anti-Tuberculosis Drugs) on Drinking Adherence. Journal of Human Asylum Nursing (JKSI), 3(2), 1–12.
[19] Setiawan, S. I., & Ascobat, P. (2019). Adverse Reactions To First-Line Anti-Tuberculosis Drugs As A Risk Factor Of Pulmonary Tuberculosis Treatment Default In Jakarta , Indonesia. 11(6).
[20] Tarmizi, S.N (2024). "TB Cases are High due to Improvement of Detection and Reporting System." Ministry of Health of the Republic of Indonesia. https://sehatnegeriku.kemkes.go.id/baca/rilis-media/ 20240129 /2644 877/high-tb-case-because-of-improvement-system-detection-and-reporting/
[21] Ummah, M. S. (2020). Tuberculosis Management. Sustainability (Switzerland), 11(1), 1–14. http://scioteca.caf.com/bitstream/handle/123456789/1091/RED2017-Eng-8ene.pdf?sequence=12&isAllowed=y%0Ahttp://dx.doi.org/10.1016/j.regsciurbeco.2008.06.005%0Ahttps://www.researchgate.net/publication/305320484_Sistem_Pembetungan_Terpusat_Strategi_Melestari
[22] World Health Organization (WHO). "Tuberculosis." https://www.who. int/indonesia /news/ campaign /tb-day 2022/factsheets# :~:text= TB%20is %20cause%20death%20largest ,%2C 1%20 million%20children%2children
[23] Yanti, S., Syamsualam, & Ahri, R. A. (2021). Effectiveness of the Directly Observed Treatment Shortcourse (DOTS) Strategy in Tuberculosis Disease Management. Journal of Muslim Community Health (JMCH), 3(1), 33–42. https://doi.org/10.52103/jmch.v3i1.784JournalHomepage:https://pasca-umi.ac.id/index.php/jmch
[24] Zukhrufina Muthiah N, Tri Cahyani, & Ainni, A. N. (2024). The Relationship between the Incidence of Side Effects of the Use of Anti-Tuberculosis Drugs and Medication Compliance in Tuberculosis Patients at the Kuwarasan Health Center, Kebumen Regency in 2023. Pharmaqueous : Scientific Journal of Pharmacy, 6(2), 76–84. https://doi.org/10.36760/jp.v6i2.649.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Ummi Nur Faidah, Eko Retnowati, Galih Kurniawan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
