Optimization of Labrasol and Tween 80 in Self Nano-Emulsiying Drug Delivery System (SNEDDS) Mefenamic Acid Using The Simplex Lattice Design Method
DOI:
https://doi.org/10.51601/ijhp.v6i2.608Abstract
Mefenamic acid is a derivative of anthranilic acid that functions as a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic. Mefenamic acid is included in the Biopharmaceutical Classification System (BCS) class II which has low solubility and high permeability. The manufacture of SNEDDS requires a non-ionic surfactant with an HLB (Hydrophilic-Lipophilic Balance) value of more than 10. Mefenamic acid has high solubility in the surfactant Labrasol which has HLB 12 and Tween 80 which has HLB 15. This study aims to develop mefenamic acid into a Self Nano-Emulsifying Drug Delivery System (SNEDDS) with the optimization of labrasol and tween 80 as surfactants. The optimization of mefenamic acid SNEDDS is made using the simplex lattice design method. In the optimization, 6 running SNEDDS formulas were obtained with mefenamic acid. Chemical physics testing includes organoleptic evaluation, pH, viscosity, percent of transmitters, emulsification time, stability, particle size, potential zeta, and level determination. The results showed that the optimal combination of labrasol and tweenat SNEDDS mefenamic acid 80, namely 24% Labrasol and 1% Tween 80, with a desirability value of 0.984, had a clear, non-rancid, homogeneous, liquid-shaped color, pH of 4.69, viscosity 31.33 cP, transmitter percentage 96.80%, emulsification time 29.11 seconds, particle size 44.30 nm, zeta potential -28.87 mV, and a polydispersivity index of 0.563, with a percentage of levels of 100.08%, 100.70%, and 99.87%, respectively.
Key words: Self Nano-Emulsifying Drug Delivery System (SNEDDS), Labrasol, Tween 80
Downloads
References
[1] Abdullah, A., & Tahar, N. (2022). Dissolution Improvement of Mefenamic Acid Through Cocrystallization with Aminobenzoic Acid Using Liquid-Assisted Grinding Method. Journal Of Pharmacy and Science), 5(2), 46–53.
[2] Ministry of Health of the Republic of Indonesia. (2020). Indonesian Pharmacopoeia Edition VI (Ministry of Health of the Republic of Indonesia, Ed.; VI). Ministry of Health of the Republic of Indonesia.
[3] Dilla, K. N., Adawiyah, R., Putri, N. C., Noval, N., & Mahdiyah, D. (2024). Formulation of Self-Nanoemulsifying Drug Delivery System Celery Extract (Apium graveolens L.) with Variation in Virgin Coconut Oil Concentration as Antihypertensive. Journal of Medical Radiation, 10(2), 55–63. https://doi.org/10.33084/jsm.v10i2.7724
[4] Fitriani, H., Fitria, A., Miladiyah, I., & Syukri, Y. (2021). Development of Self-Nano Emulsifying System (SNES) of Temulawak Extract (Curcuma xanthorrhiza): Formulation, Characterization, and Stability. Journal of Pharmaceutical & Clinical Sciences, 8(3), 332. https://doi.org/10.25077/jsfk.8.3.332-339.2021
[5] Hajrin, W., Subaidah, W. A., Juliantoni, Y., & Wirasisya, D. G. (2021). Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei). Journal of Tropical Biology, 21(2), 501–509. https://doi.org/10.29303/jbt.v21i2.2717
[6] Hastuti, E. D. (2020). Formulation of Self Nanoemulsifying Drug Delivery System (SNEDDS) Ethyl Acetate Extract of Parijoto Fruit (Medinilla speciosa Blume) and Physical Stability Test. Scholar Journal of Pharmacy, 4. http://cjp.jurnal.stikescendekiautamakudus.ac.id
[7] Muslim, N. S., Hariyadi, P., & Andarwulan, N. (2025). Optimization of the Dry Vanilla (Vanilla tahitensis JW Moore) Maceration Process in Vanilla Extract Production Using RSM. Journal of Food Quality: Indonesian Journal of Food Quality, 12(1), 47–56. https://doi.org/10.29244/jmpi.2025.12.1.47
[8] Nerdy. (2017). Validation Of Ultraviolet Spectrophotometry Method For Determination Of Mefenamic Acid Level In Suspension Dosage Forms. Natural Journal, 17(1), 17–22. https://doi.org/10.24815/jn.v17i1.6540
[9] Norliani, R., Noval, N., & Melviani, M. (2024). Stability Study of Self Nano Emulsifying Drug Delivery System (SNEDDS) Formulation of Serunai Leaf Extract as Anti-Diabetes with Variations in Oleic Acid Concentration. Scientific Journal of Ibn Sina (JIIS): Pharmaceutical and Health Sciences, 8(3), 13–24. https://doi.org/10.36387/jiis.v8i3.1646
[10] Ocktavia, R. P. (2020). Incidence of Side Effects of NSAID Use in Patients at Ngaglik 2 Sleman Health Center, Special Region of Yogyakarta.
[11] Rowe, R. C. (2017). Handbook of Pharmaceutical Excipients Eighth Edition (P. J. , C. W. G. , C. C. G. Sheskey, Ed.; 8th Edition). Pharmaceutical Press.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Silvy Aldila, Anifatus Sa’adah, Valentina Girsang, Farah Destyana Nurainy, Ummi Kalsum, Rossalina Nurul Agustin, Novita Dwi Dahliyanti
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
