Profile of Peripartum Cardiomyopathy Patients at Waled Re-gional Hospital, Cirebon Regency, January 2022 - June 2025

Authors

  • Laela Susilawati Medical Education, Universitas Swadaya Gunung Jati, Indonesia
  • Rini Istisakinah Medical Education, Universitas Swadaya Gunung Jati, Indonesia
  • Nunung Nurbaniwati Medical Education, Universitas Swadaya Gunung Jati, Indonesia

DOI:

https://doi.org/10.51601/ijhp.v6i2.628

Abstract

Peripartum cardiomyopathy (PPCM) is an important cause of heart failure during pregnancy and postpartum, but patient profile data at district hospitals such as Waled Regional Hospital, Cirebon is still very limited. This study aims to describe the profile of peripartum cardiomyopathy patients at Waled Regional Hospital, Cirebon Regency, from January 2022 to June 2025. A retrospective descriptive study design was used with secondary data analysis from the medical records of all patients diagnosed with PPCM, including variables such as age, hypertension, diabetes mellitus, parity, multiple pregnancies, hemoglobin levels, random blood sugar, urea, creatinine, and echocardiography results (LVEF). Analysis was performed with univariate frequency distribution using nominal and ordinal scales. The results showed that most patients were aged 36–45 years (45.16%), multiparous (54.84%), had grade II hypertension (39.03%), and had LVEF <40% (77.42%), while diabetes mellitus and multiple pregnancies were very rare. Thus, in this setting PPCM primarily affects elderly multiparous mothers with severe hypertension and left ventricular systolic dysfunction, highlighting the need for strengthened risk-based screening and collaborative management between obstetrics and cardiology

Downloads

Download data is not yet available.

References

[1] Al-Riyami, N., Al-Khayari, S., Al-Zadjali, R., Machado, L., Al-Madhani, A., & Al-Lawati, H. (2023). Incidence, risk factors, maternal and neonatal outcomes of peripartum cardiomyopathy (PPCM) in Oman. Global Heart, 18(1), Article 23.

[2] Arany, Z., Elkayam, U., Davis, M.B., McNamara, D.M., & Goland, S. (2020). Peripartum cardiomyopathy: JACC state-of-the-art review. Journal of the American College of Cardiology, 75(2), 207–221.https://doi.org/10.1016/j.jacc.2019.11.014

[3] Bak, S., Kim, M., Park, J.H., Lee, J., Choi, J.O., Kang, S.M., et al. (2024). Temporal trends in clinical character-istics and outcomes for peripartum cardiomyopathy: The nationwide multicenter registry over 20 years. Journal of the American Heart Association, 13(2), e034055.

[4] Biljic-Erski, A., Rajovic, N., Pavlovic, V., Bukumiric, Z., Rakic, A., Rovcanin, M., Stulic, J., Anicic, R., Kocic, J., Cumic, J., et al. (2025). Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A meta-analysis of prevalence and impact on left ventricular function and mortality. Journal of Clinical Medicine, 14, 1721. https://doi.org/10.3390/jcm14051721

[5] Chen, X., Jin, H., Wang, D., Liu, J., Qin, Y., Zhang, Y., Zhang, Y., & Xiang, Q. (2023). Serum creatinine levels, traditional cardiovascular risk factors and 10-year cardiovascular risk in Chinese patients with hypertension. Frontiers in Endocrinology, 14, 1140093. https://doi.org/10.3389/fendo.2023.1140093

[6] Cherubin, S., Peoples, T., Gillard, J., et al. (2020). Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy. Open Heart, 7, e001430. https://doi.org/10.1136/openhrt-2020-001430

[7] Creswell, J. W., & Creswell, J. D. (2025). Research design: Qualitative, quantitative, and mixed methods ap-proaches (6th ed.). Sage Publications.

[8] Echouffo-Tcheugui, J.B., Guan, J., Retnakaran, R., & Shah, B.R. (2021). Gestational diabetes and incident heart failure: A cohort study. Diabetes Care, 44(10), 2346–2352. https://doi.org/10.2337/dc21-0643

[9] Emzir. (2022). Educational research methodology: Quantitative and qualitative. Rajawali Pers.

[10] European Society of Cardiology. (2021). 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. ESC.

[11] Hilfiker-Kleiner, D., Haghikia, A., & Bauersachs, J. (2022). Peripartum cardiomyopathy: Current management and future perspectives. European Heart Journal Supplements, 24(Suppl I), I56–I62.

[12] Huang, H., Ye, Q., Xu, Y., Tao, B., Liu, J., Xie, T., & Zha, L. (2024). Risk factors and clinical features of peri-partum cardiomyopathy in a Chinese population. Journal of Multidisciplinary Healthcare, 17, 3763–3772.

[13] Jackson, A.M., Petrie, M.C., Frogoudaki, A., Laroche, C., Gustafsson, F., Ibrahim, B., et al. (2021). Hypertensive disorders in women with peripartum cardiomyopathy: Insights from the ESC EORP PPCM registry. European Journal of Heart Failure, 23(12), 2058–2069. https://doi.org/10.1002/ejhf.2338

[14] Kuc, A., Kubik, D., & Koscielecka, K. (2022). The relationship between peripartum cardiomyopathy and preeclampsia-pathogenesis. International Journal of Molecular Sciences, 23(8), 4214.

[15] Lewey, J., Levine, L.D., Elovitz, M.A., Irizarry, O.C., & Arany, Z. (2020). Importance of early diagnosis in peripartum cardiomyopathy. Circulation: Heart Failure, 13(3), e006268.

[16] Ling, H.Z., Garcia Jara, P., Nicolaides, K.H., & Kametas, N.A. (2021). Effect of maternal age on cardiac adap-tation in pregnancy. Ultrasound in Obstetrics & Gynecology, 58(2), 285–292. https://doi.org/10.1002/uog.23626

[17] Mahendra, AA, Andrianto, & Laksana, MAC (2025). Profile of maternal mortality due to cardiovascular disease based on determinant factors at Dr. Soetomo Regional General Hospital. Cardiovascular and Cardiometabolic Journal, 6(1), 1–8.

[18] Metgud, S.C., Patil, A., & Renuka, P.M. (2025). Epidemiology, risk factors, and pregnancy outcomes in peri-partum cardiomyopathy. Journal of the Scientific Society, 52, 43–48.

[19] Mohanasundari, K. P., Manonmani, R., & Pradeepa, T. (2023). Peripartum cardiomyopathy in a tertiary care hospital. International Journal of Academic Medicine and Pharmacy, 5(4), 1730–1733.

[20] Mubarik, A., Chippa, V., & Ilyas, A. (2024). Postpartum cardiomyopathy. In StatPearls. StatPearls Publishing.

[21] Notoatmodjo, S. (2021). Health research methodology. Rineka Cipta.

[22] Nugrahani, AD, Maulana, S., Tjandraprawira, KD, Santoso, DPJ, Setiawan, D., Pribadi, A., Siddiq, A., Pramatirta, AY, Aziz, MA, & Irianti, S. (2023). Analysis of clinical profiles and echocardiographic cardiac out-comes in peripartum cardiomyopathy (PPCM) vs. PPCM with co-existing hypertensive pregnancy disorder (HPD-PPCM) patients: A systematic review and meta-analysis. Journal of Clinical Medicine, 12(16), 5303. https://doi.org/10.3390/jcm12165303

[23] Prameswari, HS, Dewi, TI, Hasan, M., Martanto, E., Astuti, A., Saboe, A., et al. (2024). Clinical presentation and 6-month outcomes of patients with peripartum cardiomyopathy in Indonesia. International Journal of General Medicine, 17, 1073–1083.

[24] Sliwa, K., Bauersachs, J., Arany, Z., et al. (2021). Peripartum cardiomyopathy: From genetics to management. European Heart Journal, 42(32), 3094–3102. https://doi.org/10.1093/eurheartj/ehab196

[25] Soraya, AI, & Wisesa, S. (2022). Literature review of retrospective studies and case reports of peripartum cardiomyopathy in Indonesia. Mandala of Health, 15(2), 165–178.

[26] Sudaryono. (2021). Quantitative, qualitative, and mixed method research methodology. Rajawali Pers.

[27] Sugiyono. (2023). Quantitative, qualitative, and R&D research methods. Alfabeta.

[28] Wang, Y., Xu, X., Shi, S., et al. (2023). Blood urea nitrogen to creatinine ratio and long-term survival in patients with chronic heart failure. European Journal of Medical Research, 28, 343. https://doi.org/10.1186/s40001-023-01234-x

[29] Zhu, J., & Liu, W. (2021). Acute kidney injury predicts poor left ventricular function for patients with peripartum cardiomyopathy. BMC Cardiovascular Disorders, 21, 205. https://doi.org/10.1186/s12872-021-02054-2.

Downloads

Published

2026-05-15

How to Cite

Laela Susilawati, Rini Istisakinah, & Nunung Nurbaniwati. (2026). Profile of Peripartum Cardiomyopathy Patients at Waled Re-gional Hospital, Cirebon Regency, January 2022 - June 2025. International Journal of Health and Pharmaceutical (IJHP), 6(2), 186–195. https://doi.org/10.51601/ijhp.v6i2.628

Issue

Section

Articles