Effect Of Giving Virgin Coconut Oil And Physical Exercise On Leukocyte Levels In Non-Athlete Students
Keywords:Virgin Coconut Oil, Physical Exercise and Leukocyte
In recent years there has been an increase in the prevalence of viral infections worldwide with the outbreak of
the Coronavirus Disease. Various attempts have been made to find new drugs and vaccines against the viruses
that cause it, but there are no effective preventive and curative drugs yet, so boosting the immune system is one
of the most important things to do. One of the natural ingredients that are believed to increase the body's
immunity is Virgin Coconut Oil (VCO), but it still needs more intense research. In addition to the use of natural
ingredients, exercise is also important to maintain and increase immunity. One indicator that is sensitive to
impaired immune response is leukocytes. This study aims to see the effect of giving VCO and physical exercise
on immune function by measuring leukocyte levels. This is an experimental study with a randomized control
group pretest-posttest design. The sample in this study were 12 people who were divided into two groups.
During the exercise with an intensity of 70-80% in two weeks with a frequency of three times a week, the
experimental group was given 15 ml of VCO every day while the control group was given a placebo. Leukocyte
levels were measured before and after treatment. Leukocyte levels in the control group increased significantly
while the experimental group decreased insignificantly. Giving virgin coconut oil in this study significantly
reduced leukocyte levels.
Director-General, W. (2020). WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11
February 2020. World Health Orgnatization (WHO).
Jayawardena, R., Sooriyaarachchi, P., Chourdakis, M., Jeewandara, C., & Ranasinghe, P. (2020). Enhancing
immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes and Metabolic
Syndrome: Clinical Research and Reviews. https://doi.org/10.1016/j.dsx.2020.04.015
Mousa, H. A. L. (2017). Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by
Herbal, Complementary, and Natural Therapies. Journal of Evidence-Based Complementary and Alternative
McCarty, M. F., & DiNicolantonio, J. J. (2020). Nutraceuticals have potential for boosting the type 1 interferon
response to RNA viruses including influenza and coronavirus. In Progress in Cardiovascular Diseases.
Carandang, E. V. (2012). Health Benefits of Virgin Coconut Oil. January, 213–264.
da Silva Lima, R., & Block, J. M. (2019). Coconut oil: What do we really know about it so far? In Food Quality
and Safety. https://doi.org/10.1093/fqsafe/fyz004
Abujazia, M. A., Muhammad, N., Shuid, A. N., & Soelaiman, I. N. (2012). The effects of virgin coconut oil on
bone oxidative status in ovariectomised rat. Evidence-Based Complementary and Alternative Medicine.
Famurewa, A. C., Ekeleme-Egedigwe, C. A., Nwali, S. C., Agbo, N. N., Obi, J. N., & Ezechukwu, G. C. (2018).
Dietary Supplementation with Virgin Coconut Oil Improves Lipid Profile and Hepatic Antioxidant Status and
Has Potential Benefits on Cardiovascular Risk Indices in Normal Rats. Journal of Dietary Supplements.
Marina, A. M., Che Man, Y. B., Nazimah, S. A. H., & Amin, I. (2009). Antioxidant capacity and phenolic acids
of virgin coconut oil. International Journal of Food Sciences and Nutrition.
Sinaga, F. A., Harahap, U., Silalahi, J., & Sipahutar, H. (2019b). Antioxidant effect of virgin coconut oil on urea
and creatinine levels on maximum physical activity. Open Access Macedonian Journal of Medical Sciences.
Yeap, S. K., Beh, B. K., Ali, N. M., Yusof, H. M., Ho, W. Y., Koh, S. P., Alitheen, N. B., & Long, K. (2015).
Antistress and antioxidant effects of virgin coconut oil in vivo. Experimental and Therapeutic Medicine.
Famurewa, A. C., Maduagwuna, E. K., Folawiyo, A. M., Besong, E. E., Eteudo, A. N., Famurewa, O. A., &
Ejezie, F. E. (2020). Antioxidant, anti-inflammatory, and antiapoptotic effects of virgin coconut oil against
antibiotic drug gentamicin-induced nephrotoxicity via the suppression of oxidative stress and modulation of
iNOS/NF-ĸB/caspase-3 signaling pathway in Wistar rats. Journal of Food Biochemistry.
International Journal of Health and Pharmaceutical
Luxminarayan, L., Neha, S., Amit, V., & Khinchi, M. P. (2017). Asian Journal of Pharmaceutical Research and
Development. Asian Journal of Pharmaceutical Research and Development, 5(2), 1–8.Varma, S. R.,
Sivaprakasam, T. O., Arumugam, I., Dilip, N., Raghuraman, M., Pavan, K. B., Rafiq, M., & Paramesh, R.
(2019). In vitro anti-inflammatory and skin protective properties of Virgin coconut oil. Journal of Traditional
and Complementary Medicine, 9(1), 5–14. https://doi.org/10.1016/j.jtcme.2017.06.012
da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T.
(2020). Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the
current literature. In Clinical and Experimental Medicine. https://doi.org/10.1007/s10238-020-00650-3
Pedersen, B. K., & Hoffman-Goetz, L. (2000). Exercise and the immune system: Regulation, integration, and
adaptation. In Physiological Reviews. https://doi.org/10.1152/physrev.2000.80.3.1055
Leandro, C. G., De Castro, R. M., Nascimento, E., Pithon-Curi, T. C., & Curi, R. (2007). Adaptative
mechanisms of the immune system in response to physical training. In Revista Brasileira de Medicina do
Laddu, D. R., Lavie, C. J., Phillips, S. A., & Arena, R. (2020). Physical activity for immunity protection:
Inoculating populations with healthy living medicine in preparation for the next pandemic. In Progress in
Cardiovascular Diseases. https://doi.org/10.1016/j.pcad.2020.04.006
Simpson, R. J., & Katsanis, E. (2020). The immunological case for staying active during the COVID-19
pandemic. In Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2020.04.041
Parsons, T. J., Sartini, C., Welsh, P., Sattar, N., Ash, S., Lennon, L. T., Wannamethee, S. G., Lee, I. M.,
Whincup, P. H., & Jefferis, B. J. (2017). Physical Activity, Sedentary Behavior, and Inflammatory and
Hemostatic Markers in Men. Medicine and Science in Sports and Exercise.
Tauler, P., & Aguiló, A. (2010). The anti-inflammatory effects of exercise. In The Anti-Inflammatory Effects of
Zimmer, P., Bloch, W., Schenk, A., Zopf, E. M., Hildebrandt, U., Streckmann, F., Beulertz, J., Koliamitra, C.,
Schollmayer, F., & Baumann, F. (2015). Exercise-induced natural killer cell activation is driven by epigenetic
modifications. International Journal of Sports Medicine. https://doi.org/10.1055/s-0034-1398531
Gleeson, M. (2002). Biochemical and immunological markers of overtraining. In Journal of Sports Science and
Green KJ, Rowbottom DG, Mackinnon LT. Exercise and T-Lymphocyte function: a comparison of proliferation
in PBMC and NK cell-depleted PBMC culture. J Appl Physiol. 2002:92:2390-2395.
Edwards KM, Burns VE, Carrol D, et al. The acute stress-induced immunoenhancement hypothesis. Exerc Sport
Sci Rev. 2007:35:150-155.
McCarthy DA, Dale MM. The leucocytosis of exercise.A review and model. Sports Med 1988; 6:333-363.
Kristin L Sand , Torun Flatebo , Marian bergeanderrsen , Azzam A Maghazachi , Effects of exercise on
leukocytosis and blood hemostasis in 800 healthy young females and males , world journal of experimental
medicine 2013; 3(1):11 https://doi.org/10.5493/wjem.v3.i1.11
Anwer RM, Babiker NE, The Effect of Exercise on the Total Leukocyte, Absolute Neutrophil, Lymphocyte and
Platelet Counts among Sudanese Football Players, Journal of Drug Delivery and Therapeutics. 2021; 11(6-
S):26-32. DOI: http://dx.doi.org/10.22270/jddt.v11i6-S.5109
Syamsunarno, Mas & Fauziah Agustin, Dinar & Anggraeni, Neni & Kania, Nia. (2020). Effect of Fish Oil,
Virgin Coconut Oil, and Used-Cooking Oil Consumption on Hematological Profile in Mice. Indonesian
Journal of Clinical Pharmacy. 9. 137. 10.15416/ijcp.2020.9.2.137. DOI:10.15416/ijcp.2020.9.2.137.
Handajani NS, Dharmawan R. Effect of VCO to leucocyte differential count, glucose levels and blood creatinine
of hyperglycemic and ovalbumin sensitized Mus musculus Balb/c. Nusantara Bioscience 2009; 1(1):1-8.
Ahmad, B. et al. Beneficial effects of coconut oil (Cocos nucifera) on hematobiochemicl and histopathological
markers in CCL4- intoxicated rabbits. Brazilian Journal of Biology, 2024, vol. 84, e252555 |
Widianingrum & Salasia. Immunomodulatory effects of virgin coconut oil in wistar rats infected with
Staphylococcus aureus. JITV Vol. 26 No. 1 Th. 2021: 31-38.
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