Effect Of Giving Virgin Coconut Oil And Physical Exercise On Leukocyte Levels In Non-Athlete Students

Authors

  • Rika Nailuvar Sinaga Department of Sports Science Faculty Universitas Negeri Medan, Indonesia
  • Fajar Apollo Sinaga Department of Sports Science Faculty Universitas Negeri Medan, Indonesia
  • Ayu Elvana Department of Sports Science Faculty Universitas Negeri Medan, Indonesia

DOI:

https://doi.org/10.51601/ijhp.v4i4.255

Keywords:

Virgin Coconut Oil, Physical Exercise and Leukocyte

Abstract

In recent years there has been an increase in the prevalence of viral infections worldwide with the outbreak of
the Coronavirus Disease. Various attempts have been made to find new drugs and vaccines against the viruses
that cause it, but there are no effective preventive and curative drugs yet, so boosting the immune system is one
of the most important things to do. One of the natural ingredients that are believed to increase the body's
immunity is Virgin Coconut Oil (VCO), but it still needs more intense research. In addition to the use of natural
ingredients, exercise is also important to maintain and increase immunity. One indicator that is sensitive to
impaired immune response is leukocytes. This study aims to see the effect of giving VCO and physical exercise
on immune function by measuring leukocyte levels. This is an experimental study with a randomized control
group pretest-posttest design. The sample in this study were 12 people who were divided into two groups.
During the exercise with an intensity of 70-80% in two weeks with a frequency of three times a week, the
experimental group was given 15 ml of VCO every day while the control group was given a placebo. Leukocyte
levels were measured before and after treatment. Leukocyte levels in the control group increased significantly
while the experimental group decreased insignificantly. Giving virgin coconut oil in this study significantly
reduced leukocyte levels.

References

Director-General, W. (2020). WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11

February 2020. World Health Orgnatization (WHO).

Jayawardena, R., Sooriyaarachchi, P., Chourdakis, M., Jeewandara, C., & Ranasinghe, P. (2020). Enhancing

immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes and Metabolic

Syndrome: Clinical Research and Reviews. https://doi.org/10.1016/j.dsx.2020.04.015

Mousa, H. A. L. (2017). Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by

Herbal, Complementary, and Natural Therapies. Journal of Evidence-Based Complementary and Alternative

Medicine. https://doi.org/10.1177/2156587216641831

McCarty, M. F., & DiNicolantonio, J. J. (2020). Nutraceuticals have potential for boosting the type 1 interferon

response to RNA viruses including influenza and coronavirus. In Progress in Cardiovascular Diseases.

https://doi.org/10.1016/j.pcad.2020.02.007

Carandang, E. V. (2012). Health Benefits of Virgin Coconut Oil. January, 213–264.

https://doi.org/10.1177/0146167201277003

da Silva Lima, R., & Block, J. M. (2019). Coconut oil: What do we really know about it so far? In Food Quality

and Safety. https://doi.org/10.1093/fqsafe/fyz004

Abujazia, M. A., Muhammad, N., Shuid, A. N., & Soelaiman, I. N. (2012). The effects of virgin coconut oil on

bone oxidative status in ovariectomised rat. Evidence-Based Complementary and Alternative Medicine.

https://doi.org/10.1155/2012/525079

Famurewa, A. C., Ekeleme-Egedigwe, C. A., Nwali, S. C., Agbo, N. N., Obi, J. N., & Ezechukwu, G. C. (2018).

Dietary Supplementation with Virgin Coconut Oil Improves Lipid Profile and Hepatic Antioxidant Status and

Has Potential Benefits on Cardiovascular Risk Indices in Normal Rats. Journal of Dietary Supplements.

https://doi.org/10.1080/19390211.2017.1346031

Marina, A. M., Che Man, Y. B., Nazimah, S. A. H., & Amin, I. (2009). Antioxidant capacity and phenolic acids

of virgin coconut oil. International Journal of Food Sciences and Nutrition.

https://doi.org/10.1080/09637480802549127

Sinaga, F. A., Harahap, U., Silalahi, J., & Sipahutar, H. (2019b). Antioxidant effect of virgin coconut oil on urea

and creatinine levels on maximum physical activity. Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2019.503

Yeap, S. K., Beh, B. K., Ali, N. M., Yusof, H. M., Ho, W. Y., Koh, S. P., Alitheen, N. B., & Long, K. (2015).

Antistress and antioxidant effects of virgin coconut oil in vivo. Experimental and Therapeutic Medicine.

https://doi.org/10.3892/etm.2014.2045

Famurewa, A. C., Maduagwuna, E. K., Folawiyo, A. M., Besong, E. E., Eteudo, A. N., Famurewa, O. A., &

Ejezie, F. E. (2020). Antioxidant, anti-inflammatory, and antiapoptotic effects of virgin coconut oil against

antibiotic drug gentamicin-induced nephrotoxicity via the suppression of oxidative stress and modulation of

iNOS/NF-ĸB/caspase-3 signaling pathway in Wistar rats. Journal of Food Biochemistry.

https://doi.org/10.1111/jfbc.13100

International Journal of Health and Pharmaceutical

https://ijhp.net

Luxminarayan, L., Neha, S., Amit, V., & Khinchi, M. P. (2017). Asian Journal of Pharmaceutical Research and

Development. Asian Journal of Pharmaceutical Research and Development, 5(2), 1–8.Varma, S. R.,

Sivaprakasam, T. O., Arumugam, I., Dilip, N., Raghuraman, M., Pavan, K. B., Rafiq, M., & Paramesh, R.

(2019). In vitro anti-inflammatory and skin protective properties of Virgin coconut oil. Journal of Traditional

and Complementary Medicine, 9(1), 5–14. https://doi.org/10.1016/j.jtcme.2017.06.012

da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T.

(2020). Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the

current literature. In Clinical and Experimental Medicine. https://doi.org/10.1007/s10238-020-00650-3

Pedersen, B. K., & Hoffman-Goetz, L. (2000). Exercise and the immune system: Regulation, integration, and

adaptation. In Physiological Reviews. https://doi.org/10.1152/physrev.2000.80.3.1055

Leandro, C. G., De Castro, R. M., Nascimento, E., Pithon-Curi, T. C., & Curi, R. (2007). Adaptative

mechanisms of the immune system in response to physical training. In Revista Brasileira de Medicina do

Esporte. https://doi.org/10.1590/S1517-86922007000500012

Laddu, D. R., Lavie, C. J., Phillips, S. A., & Arena, R. (2020). Physical activity for immunity protection:

Inoculating populations with healthy living medicine in preparation for the next pandemic. In Progress in

Cardiovascular Diseases. https://doi.org/10.1016/j.pcad.2020.04.006

Simpson, R. J., & Katsanis, E. (2020). The immunological case for staying active during the COVID-19

pandemic. In Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2020.04.041

Parsons, T. J., Sartini, C., Welsh, P., Sattar, N., Ash, S., Lennon, L. T., Wannamethee, S. G., Lee, I. M.,

Whincup, P. H., & Jefferis, B. J. (2017). Physical Activity, Sedentary Behavior, and Inflammatory and

Hemostatic Markers in Men. Medicine and Science in Sports and Exercise.

https://doi.org/10.1249/MSS.0000000000001113

Tauler, P., & Aguiló, A. (2010). The anti-inflammatory effects of exercise. In The Anti-Inflammatory Effects of

Exercise.

Zimmer, P., Bloch, W., Schenk, A., Zopf, E. M., Hildebrandt, U., Streckmann, F., Beulertz, J., Koliamitra, C.,

Schollmayer, F., & Baumann, F. (2015). Exercise-induced natural killer cell activation is driven by epigenetic

modifications. International Journal of Sports Medicine. https://doi.org/10.1055/s-0034-1398531

Gleeson, M. (2002). Biochemical and immunological markers of overtraining. In Journal of Sports Science and

Medicine.

Green KJ, Rowbottom DG, Mackinnon LT. Exercise and T-Lymphocyte function: a comparison of proliferation

in PBMC and NK cell-depleted PBMC culture. J Appl Physiol. 2002:92:2390-2395.

Edwards KM, Burns VE, Carrol D, et al. The acute stress-induced immunoenhancement hypothesis. Exerc Sport

Sci Rev. 2007:35:150-155.

McCarthy DA, Dale MM. The leucocytosis of exercise.A review and model. Sports Med 1988; 6:333-363.

https://doi.org/10.2165/00007256-198806060-00002

Kristin L Sand , Torun Flatebo , Marian bergeanderrsen , Azzam A Maghazachi , Effects of exercise on

leukocytosis and blood hemostasis in 800 healthy young females and males , world journal of experimental

medicine 2013; 3(1):11 https://doi.org/10.5493/wjem.v3.i1.11

Anwer RM, Babiker NE, The Effect of Exercise on the Total Leukocyte, Absolute Neutrophil, Lymphocyte and

Platelet Counts among Sudanese Football Players, Journal of Drug Delivery and Therapeutics. 2021; 11(6-

S):26-32. DOI: http://dx.doi.org/10.22270/jddt.v11i6-S.5109

Syamsunarno, Mas & Fauziah Agustin, Dinar & Anggraeni, Neni & Kania, Nia. (2020). Effect of Fish Oil,

Virgin Coconut Oil, and Used-Cooking Oil Consumption on Hematological Profile in Mice. Indonesian

Journal of Clinical Pharmacy. 9. 137. 10.15416/ijcp.2020.9.2.137. DOI:10.15416/ijcp.2020.9.2.137.

Handajani NS, Dharmawan R. Effect of VCO to leucocyte differential count, glucose levels and blood creatinine

of hyperglycemic and ovalbumin sensitized Mus musculus Balb/c. Nusantara Bioscience 2009; 1(1):1-8.

Ahmad, B. et al. Beneficial effects of coconut oil (Cocos nucifera) on hematobiochemicl and histopathological

markers in CCL4- intoxicated rabbits. Brazilian Journal of Biology, 2024, vol. 84, e252555 |

https://doi.org/10.1590/1519-6984.252555

Widianingrum & Salasia. Immunomodulatory effects of virgin coconut oil in wistar rats infected with

Staphylococcus aureus. JITV Vol. 26 No. 1 Th. 2021: 31-38.

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Published

2024-11-26

How to Cite

Nailuvar Sinaga, R., Apollo Sinaga, . F., & Elvana, A. . (2024). Effect Of Giving Virgin Coconut Oil And Physical Exercise On Leukocyte Levels In Non-Athlete Students. International Journal of Health and Pharmaceutical (IJHP), 4(4), 630–633. https://doi.org/10.51601/ijhp.v4i4.255