Test Of the Effectiveness of Tomato (Lycopersicum Esculentum Mill) Fruit Extract Cream on Increasing Elasticity, Sebum and Hydration in White Mouse Skin (Mus Musculus)
DOI:
https://doi.org/10.51601/ijhp.v3i3.171Keywords:
Tomato, Elasticity, Sebum, Hydration and Anti-Aging.Abstract
The skin is the outermost organ that acts as a protector from the external environment both in the ligaments, muscles, and internal organs from exposure to direct sunlight (ultraviolet light) and dehydration, also functions as a sense of taste and touch as well as a defense against pressure and infection. The imbalance between oxidants and antioxidants is influenced by external factors and internal factors that will affect wrinkling and aging of the skin. Tomatoes contain substances such as citrulline, vitamin A, vitamin B2, vitamin B6, vitamin E, vitamin C, and protein, beta-carotene, lycopene, and water. The purpose of this study was to determine the activity of tomato fruit ethanol extract to increase elasticity, sebum and hydration in the skin of male white mice. Cream preparations of tomato fruit ethanol extract were formulated with concentrations of 2.5%, 5%, and 10%. The test was carried out on the skin of male mice for 4 weeks by measuring the levels of elasticity, sebum and hydration. The results of phytochemical screening of extracts contained flavonoids, saponins, steroids, triterpenoids, and glycosides. The measurement results in the fourth week of each group of cream preparations showed an increase in the levels of elasticity, sebum and hydration and was significantly different from the blank group (p<0.05) and the highest increase occurred in cream with 10% tomato extract concentration. The results of this study indicate that the preparation of tomato fruit ethanol extract cream can increase the elasticity, sebum and hydration levels of the skin.
References
Basler, K., Bergmann, S., Heisig, M., Naegel, A., Zom-Kruppa, M and Brandner, J.M. (2016). The Role of Tight Junction in Skin Barrier Function and Dermal Absorption. Journal of Controlled Release. Elsevier. Volume 242, 28 November 2016, Pages 105-118. https://doi.org/10.1016/j.jconrel.2016.08.007
Jia, N., Li, T., Diao, X & Kong, B, B., (2014). Protective Effects Of Black Currant (Ribes Nigrum L.) Extract On Hydrogen Peroxide-Induced Damage In Lung Fibroblast MRC-5 Cells In Relation To The Antioxidant Activity. Journal of Functional Foods, Elsevier. Volume 11, November 2014, Pages 142-151. https://doi.org/10.1016/j.jff.2014.09.011
Kim, D.-B., Shin, G.-H., Kim, J.-M., Kim, Y.-H., Lee, J.-H., Lee, J.-H., Lee, J.S., Song, H.-J., Choe, S.Y., Park, I.-J., Cho, J.-H., Lee, O.-H., (2016). Antioxidant and Anti Aging Activities of Citrus-Based Juice Mixture. Food Chemistry, Elsevier. Volume 194, 1 March 2016, Pages 920-927. https://doi.org/10.1016/j.foodchem.2015.08.094
Cunningham W. (2003). Aging and Photo-Aging. Dalam: Baran R, Maibach HI editor. Textbook of Cosmetic Deramtology. Edisi ke-2 London: MartinDunitz: 455-468.
Yaar, M & Gilchrest, BA. (2007). Photoaging: Mechanism, Prevention and Therapy. British Journal of Dermatology, Willey. Vol. 157: pp. 874-877. https://doi.org/10.1111/j.1365-2133.2007.08108.x
Polsjak B, Dahmane RG and Godic A. (2012). Intrinsic Skin Aging: The Role of Oxidative Stress. Acta Dermatovenerol - Alpina, Pannonica et Adriatica; 21: 33-6. doi: 10.2478/v10162-012-0012-5
Jingye Yang, Huzefa Dungrawala, Hui Hua, Arkadi Manukyan, Lesley Abraham, Wesley Lane, Holly Mead, Jill Wright & Brandt L. Schneider (2011) Cell Size and Growth Rate Are Major Determinants of Replicative Lifespan, Cell Cycle, 10:1, 144-155, DOI: 10.4161/cc.10.1.14455
Cheeseman, K.H. and Slater, T.F. (1993). An Introduction to Free-Radical Biochemistry. British Medical Bulletin, Volume 49, Issue 3, 1993, Pages 481–493, https://doi.org/10.1093/oxfordjournals.bmb.a072625
Smith, S. & Baylis, J. (2001). The Globalization of World Politics: An Introduction to International Relations. New York: Oxford University Press.
Kesuma S & Yenrina R. (2015). Antioksidan Alami dan Sintetik. Andalas University Press. 10-16
Rochmatika, L. D., Kusumastuti, H., Setyaningrum, G. D. & Muslihah, N. I. (2012). Analisis Kadar Antioksidan pada Masker Wajah Berbahan Dasar Lapisan Putih Kulit Semangka (citrullus vulgaris schrad). Prosiding Seminar Nasional Penelitian, Pendidikan dan Penerapan MIPA. Universitas Negeri Yogyakarta, 2 Juni 2012. http://staffnew.uny.ac.id/upload/132128276/penelitian/prosiding+semnas+mipa+uny+2012.pdf
Daniel, Andri. (2006). Intensif Bertanam Semangka Tanpa Biji. Yogyakarta: Pustaka Baru Press
Tadmor, Y., King, S., Levi, A., Davis, A., & Hirschberg, J. (2005). Comparative Fruit Coloration in Watermelon and Tomato. Food Research International, Elsevier. Volume 38, Issues 8–9, Pages 837-841. https://doi.org/10.1016/j.foodres.2004.07.011
Fitri Nuraeni, Yoga Handoko Agustin dan Endah Nirwani Yusup (2016). Aplikasi Pakar Untuk Diagnosa Penyakit Kulit Menggunakan Metode Forward Chaining di Al Arif Skin Care Kabupaten Ciamis. Seminar Nasional Teknologi Informasi dan Multimedia 2016. STMIK AMIKOM Yogyakarta, 6-7 Februari 2016. https://ojs.amikom.ac.id/index.php/semnasteknomedia/article/view/1310
Pardiansyah, R., (2015). Association Between Personal Protective Equipment with the Irritant Contact Dermatitis in Scavengers. Faculty of Medicine, Lampung University. Vol 4, No 4. https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/585
R. D. Lockhart, G. F. Hamilton, and F. W (1959) Anatomy of The Human Body, Lippincott Co., Philadelphia. 1959
Mescher, A.L. (2010). Junqueira’s Basic Histology Text & Atlas: Connective Tissue. Singapore: The McGraw-Hill Companies, Inc. p. 94-98
Sonny J. R. Kalangi (2013). Histofisiologi Kulit. Jurnal Bio Medik. Vol 5, No 3. DOI: https://doi.org/10.35790/jbm.5.3.2013.4344
Djuanda Adhi. (2007). Ilmu Penyakit Kulit Dan Kelamin. Edisi kelima. Balai Penerbit FKUI. Jakarta
Rachmi Primadiati (2001). Kecantikan, Kosmetika & Estetika. Jakarta: PT Gramedia Pustaka Utama.
Almine, J.F., Bax, D.V., Mithieux, S.M., Nivison-Smith, L., Rnjak, J., Waterhouse, A., Wise, S.G., and Weiss, A.S. (2010). Elastin-Based Materials. Chemical Society Review. Issue 9, volume 39, pp.3373-3379
Menon, G. (2015). Skin Basics; Structure and Function. In: Pappas, A. (eds) Lipids and Skin Health. Springer, Cham. https://doi.org/10.1007/978-3-319-09943-9_2
Scott, D. and Bennion, M.S. (2011). Structure and Function of the Skin. In: Fitzpatrick, J.E., Morelli, J.G., editors. Dermatology Secret Plus. Fourth Edition. Philadelphia: Elsevier Mosby. p. 6-14
Mojumdar, E.H., Pham, Q.D., Topgaard, D. & Sparr, M (2017). Skin Hydration: Interplay Between Molecular Dynamics, Structure and Water Uptake in The Stratum Corneum. Scientific Reports.Seri 7, No. 15712 (2017). https://doi.org/10.1038/s41598-017-15921-5
Pangkahila, Wimpie. (2007). Anti-Aging Medicine: Memperlambat Penuaan, Meningkatkan Kualitas Hidup. Jakarta: PT Kompas Media Nusantara
Nila Surya Atmaja, Marwiyah, Erna Setyowati (2012). Pengaruh Kosmetika Anti Aging Wajah Terhadap Hasil Perawatan Kulit Wajah. Beauty & Beauty Health Education, UNINES Journal, Vol 1, No 1. https://doi.org/10.15294/bbhe.v1i1.328
Nugroho, Wahjudi. (2000). Keperawatan Gerontik. Jakarta: Penerbit Buku Kedokteran EGC.
Padila. (2013). Buku Ajar Keperawatan Gerontik. Yogyakarta: Nuha Medika
Fowler, B. (2003), Functional and Biological Markers of Aging, In: Klatz, R. Anti-Aging Medical Therapeutics volume 5, Chicago: the AFM Publications.
Sharkey, B.J (2003). Fitness And Health. Jakarta: PT. Raja Grafindo Persada
Pangkahila J. Alex. (2013). Pengaturan Pola Hidup dan Aktivitas Fisik Meningkatkan Umur Harapan Hidup. Sport and Fitness Journal. Volume 1, No. 1: 1 – 7,
Carolina, Chyntia. C. (2010). Makanan Dan Minuman Awet Muda. Jogjakarta: Mutiara
Barel, A.O., Marc P., dan Howard, I.M. (2009). Handbook of Cosmetic Science and Technology. Edisi III. New York: Informa Healthcare. Halaman 473-475
Muliyawan, D. dan Suriana, (2013). A-Z Tentang Kosmetik. Jakarta: PT Elex Media Komputindo. Hal. 138 - 290
Aramo. (2012). Skin and Hair Diagnostic System. Sugnam: Aram Huvis Korea Ltd. p. 2-10
Sulaiman, T.N. dan Kuswahyuning, .2008. Teknologi dan Formulasi Sediaan Sedian Semipadat, Pustaka Laboratorium Teknologi Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta.
Pratiwi, P., M Suzery, B Cahyono. (2010). Total Fenolat Dan Flavonoid Dari Ekstrak Dan Fraksi Daun Kumis Kucing (Orthoshipon Stamineus B.) Jawa Tengah Serta Aktivitas Antioksidannya. Jurnal Sains & Matematika. 18 (4): 140-149.
Depkes RI. (1995). Materia Medika Indonesia. Jilid VI. Cetakan Keenam. Jakarta: Departemen Kesehatan Republik Indonesia. Halaman 258-261, 298-307,325-338
Farnsworth N.R., Henry L.K., & Svoboda G.H (1966). Biological And Phytochemical Evaluation of Plants. I. Biological Test Procedures and Results from Two Hundred Accessions.
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