Test Of The Effectiveness Of Giving Aloe Vera Extract In Reducing Cholesterol In Male Wistar Rats (Rattus Norvegicus) With Hypercholesterolemia
DOI:
https://doi.org/10.51601/ijhp.v3i4.304Keywords:
Aloe Vera, Hypercholesterolemia and Cholesterol.Abstract
Obesity prevention can be done with diet and exercise. Since plasma cholesterol levels are associated with
diabetes, public interest in diabetes treatment in foods and herbal medicines has increased dramatically.
This research wants to confirm and maximize topical plant treatment and diabetes medication benefits. This
study employs a lab experiment. Aloe vera was examined for cholesterol-lowering capacity in
hypercholesterolemic male Wistar rats (Rattus Norwegian) utilizing a pre-test-post-test control group. Aloe
vera extract (Aloe vera) reduces cholesterol, body weight, and LDL in hypercholesterolemia-afflicted male
Wistar white rats (Rattus norvegicus). One-way ANOVA test results show a significant value of 0.000 or less
than 0.05. These statistics show a substantial difference between the control and treatment groups. This
study's Post Hoc LSD test analysis indicated significance values of 0.000 and 0.018 or less than 0.05,
indicating that all groups differed. Aloe vera extract reduces LDL significantly, and the group with a
concentration of 4.5% reduced LDL levels more than the other groups in Wistar male white rats (Rattus
norvegicus) with hypercholesterolemia.
References
C. F. Lin, Y. H. Chang, S. C. Chien, Y. H. Lin, and H. Y. Yeh, “Epidemiology of Dyslipidemia in the Asia Pacific Region,” Int. J. Gerontol., vol. 12, no. 1, pp. 2–6, 2018, doi: 10.1016/j.ijge.2018.02.010.
P. Newsholme, K. N. Keane, R. Carlessi, and V. Cruzat, “Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: Importance to cell metabolism, function, and dysfunction,” Am. J. Physiol. - Cell Physiol., vol. 317, no. 3, pp. C420–C433, 2019, doi: 10.1152/ajpcell.00141.2019.
Y. Tan, S. K. C. Chang, and Y. Zhang, “Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera,” Food Chem., vol. 214, pp. 259–268, 2017, doi: 10.1016/j.foodchem.2016.06.100.
Y. G. Latuhihin, T. Watuguly, P. Kakisina, and I. Kustarini Samsuria, “Potential of Binahong (Anredera cordifolia [Tenore] Steen) in Reducing TNF-α Expression on Regeneration of Pancreas β Cells on White Rats (Rattus norvegicus) Diabetes Mellitus Models,” J. Biosci. Med., vol. 08, no. 06, pp. 37–49, 2020, doi: 10.4236/jbm.2020.86004.
S. S. Virani et al., Heart disease and stroke statistics—2020 update a report from the American Heart Association, vol. 141, no. 9. 2020. doi: 10.1161/CIR.0000000000000757.
IDF Committee, International Diabetes Federation Atlas, 9th ed. Online Edition: Pfizer - MSD - Alliance - Lilly - Novo Nordisk, 2019. doi: 10.1016/S0140-6736(55)92135-8.
J. A. Duke, M. J. Bogenschutz-Godwin, J. DuCellier, P.-A. K. Duke, and R. Kumar, Handbook of Medicinal Herbs Second Edition, Kindle Edi., vol. 5, no. 1. Florida: CRC Press, 2022. doi: 10.1097/00004850-199001000-00014.
B. A. Franklin, T. M. H. Eijsvogels, A. Pandey, J. Quindry, and P. P. Toth, “Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise train,” Am. J. Prev. Cardiol., vol. 12, no. September, p. 100425, 2022, doi: 10.1016/j.ajpc.2022.100425.
F. Thielecke and M. Boschmann, “The potential role of green tea catechins in the prevention of the metabolic syndrome - A review,” Phytochemistry, vol. 70, no. 1, pp. 11–24, 2009, doi: 10.1016/j.phytochem.2008.11.011.
A. T. A. Nanis and R. Bakhtiar, “Dislipidemia Dengan Riwayat Pengobatan Tradisional: Studi Kasus Dengan Pendekatan Kedokteran Keluarga,” J. Kedokt. Mulawarman, vol. 7, no. 3, p. 34, 2020, doi: 10.30872/j.ked.mulawarman.v7i3.4615.
J. Chen and X. Li, “Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice,” Asia Pac. J. Clin. Nutr., vol. 16, no. SUPPL.1, pp. 290–294, 2007.
F. Keivani Nahr, B. Ghanbarzadeh, H. Samadi Kafil, H. Hamishehkar, and M. Hoseini, “The colloidal and release properties of cardamom oil encapsulated nanostructured lipid carrier,” J. Dispers. Sci. Technol., vol. 42, no. 1, pp. 1–9, 2020, doi: 10.1080/01932691.2019.1658597.
K. R. Feingold, “Lipid and Lipoprotein Metabolism,” Endocrinol. Metab. Clin. North Am., vol. 51, no. 3, pp. 437–458, 2022, doi: 10.1016/j.ecl.2022.02.008.
T. C. Wallace, “Health Effects of Coconut Oil—A Narrative Review of Current Evidence,” J. Am. Coll. Nutr., vol. 38, no. 2, pp. 97–107, 2019, doi: 10.1080/07315724.2018.1497562.
M. K. Untari and G. E. Pramukantoro, “Aktivitas Antihiperkolesterolemia Ekstrak Etanol Daun Stevia Rebaudiana Bertoni Pada Tikus Putih Jantan,” J. Syifa Sci. Clin. Res., vol. 2, no. 1, pp. 11–20, 2020, doi: 10.37311/jsscr.v2i1.2700.
P. Libby, “The changing landscape of atherosclerosis,” Nature, vol. 592, no. 7855, pp. 524–533, 2021, doi: 10.1038/s41586-021-03392-8.
H. S. Cheema and M. P. Singh, “The Use of Medicinal Plants in Digestive System Related Disorders- A Systematic Review,” J. Ayurvedic Herb. Med., vol. 7, no. 3, pp. 182–187, 2021, doi: 10.31254/jahm.2021.7303.
Y. Qiu et al., “Exercise sustains the hallmarks of health,” J. Sport Heal. Sci., vol. 12, no. 1, pp. 8–35, 2023, doi: 10.1016/j.jshs.2022.10.003.
F. Haghani, M. R. Arabnezhad, S. Mohammadi, and A. Ghaffarian-Bahraman, “Aloe vera and Streptozotocin-Induced Diabetes Mellitus,” Rev. Bras. Farmacogn., vol. 32, no. 2, pp. 174–187, 2022, doi: 10.1007/s43450-022-00231-3.
M. N. zadeh Gharaboghaz, M. R. Farahpour, and S. Saghaie, “Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model,” Biomed. Pharmacother., vol. 127, no. April 2019, p. 110189, 2020, doi: 10.1016/j.biopha.2020.110189.
N. Deora and K. Venkatraman, “Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies,” J. Ayurveda Integr. Med., vol. 13, no. 4, p. 100675, 2022, doi: 10.1016/j.jaim.2022.100675.
T. Chakraborty, S. Gupta, A. Nair, S. Chauhan, and V. Saini, “Wound healing potential of insulin-loaded nanoemulsion with Aloe vera gel in diabetic rats,” J. Drug Deliv. Sci. Technol., vol. 64, no. April, p. 102601, 2021, doi: 10.1016/j.jddst.2021.102601.
C. N. Ginting, I. N. E. Lister, E. Girsang, D. Riastawati, H. S. W. Kusuma, and W. Widowati, “Antioxidant Activities of Ficus elastica Leaves Ethanol Extract and Its Compounds,” Mol. Cell. Biomed. Sci., vol. 4, no. 1, p. 27, 2020, doi: 10.21705/mcbs.v4i1.86.
N. Rohmawati, “Efek Penyembuhan Luka Bakar Dalam Sediaan Gel Ekstrak Etanol 70 % Daun Lidah Buaya ( Aloe Vera L .) Pada Kulit Punggung Kelinci New Zealand Nina Rohmawati K 100040151 Fakultas Farmasi,” Universitas Muhammadiyah Surakarta, 2008.
S. Notoatmodjo, Metodologi Penelitian Kesehatan, 3rd ed. Jakarta: Rineka Cipta, 2018.
B. Suwarno and A. Nugroho, Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi & Artikel Publikasi), 1st ed. Bogor: Halaman Moeka Publishing, 2023.
B. T. Tamon, M. Tiho, and S. H. M. Kaligis, “Efek Antioksidan pada Teh Hijau terhadap Kadar Kolesterol Darah,” J. e-Biomedik, vol. 9, no. 2, pp. 151–159, 2021, doi: 10.35790/ebm.v9i2.31869.
Setiadi, “Pengaruh Ekstrak Kulit Lidah Buaya Terhadap Kadar Gula Darah Dan Gambaran Histopatologi Pankreas Tikus Yang Diinduksi Aloksan,” Life Sci. 9, vol. 9 (2), no. 2, pp. 171–185, 2020.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Henni Gustian, Hendy Million, Horas Rajagukguk
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
